Insulin-like growth factor I modulated endothelial cell chemotaxis

M. Grant, J. Jerdan, T. J. Merimee

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Insulin-like growth factor I (IGF-I) significantly promoted chemotaxis in three separate endothelial cell lines at concentrations ranging from 4 to 150 ng/ml. When added to minimum essential medium (MEM) supplemented with 1% fetal calf serum, IGF-I augmented chemotaxis to a level equalling the maximal chemotactic effect obtainable with MEM supplemented with 10% fetal calf serum (FCS 10%). The data are compatible with a potential role for IGF-I in neovascularization.

Original languageEnglish (US)
Pages (from-to)370-371
Number of pages2
JournalJournal of Clinical Endocrinology and Metabolism
Volume65
Issue number2
StatePublished - 1987
Externally publishedYes

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Endothelial cells
Chemotaxis
Insulin-Like Growth Factor I
Endothelial Cells
Serum
Cell Line

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin-like growth factor I modulated endothelial cell chemotaxis. / Grant, M.; Jerdan, J.; Merimee, T. J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 65, No. 2, 1987, p. 370-371.

Research output: Contribution to journalArticle

Grant, M. ; Jerdan, J. ; Merimee, T. J. / Insulin-like growth factor I modulated endothelial cell chemotaxis. In: Journal of Clinical Endocrinology and Metabolism. 1987 ; Vol. 65, No. 2. pp. 370-371.
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