INsulin-like growth factor-i modulates endothelial cell chemotaxis

Maria Grant, Janice Jerdan, Thomas J. Merimee

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Insulin-like growth factor-I (IGF-I) significantly promoted chemotaxis in three separate endothelial cell lines at concentrations ranging from 4 to 150 ng/ml. When added to minimum essential medium (MEM) supplemented with 1% fetal calf serum, IGF-I augmented chemotaxis to a level equalling the maximal chemotactic effect obtainable with MEM supplemented with 10% fetal calf serum (FCS 10%). The data are compatible with a potential role for IGF-I in neovascularization.

Original languageEnglish (US)
Pages (from-to)370-371
Number of pages2
JournalJournal of Clinical Endocrinology and Metabolism
Volume65
Issue number2
DOIs
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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