Insulin Resistance Causes Human Gallbladder Dysmotility

Attila Nakeeb, Anthony G. Comuzzie, Hayder Al-Azzawi, Gabriele E. Sonnenberg, Ahmed H. Kissebah, Henry A. Pitt

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones. A growing body of animal and human data has correlated insulin resistance with organ dysfunction. The relationship among obesity, diabetes, hyperlipidemia, and abnormal gallbladder motility remains unclear. Therefore, we designed a study to investigate the association among obesity, insulin resistance, hyperlipidemia, and gallbladder dysmotility. One hundred ninety-two healthy adult nondiabetic volunteers were studied. Gallbladder ultrasounds were performed before and after a standardized fatty meal. A gallbladder ejection fraction (EF) was calculated, and an EF of <25% was considered abnormal. Serum was analyzed for cholesterol, triglycerides, cholecystokinin, leptin, glucose, and insulin. The homeostasis assessment model (HOMA) was used to determine insulin resistance. The volunteers had a mean age of 38 years (range, 18-77), and 55% were female. Thirty subjects (15%) had gallstones and were excluded from the study. Thirty subjects (19%) had abnormal gallbladder motility (EF <25%). In lean subjects (n = 96) fasting glucose was significantly increased in the 16 subjects with gallbladder EF <25% versus the 80 subjects with gallbladder EF >25% (109 ± 20 mg/dl versus 78 ± 2 mg/dl, P < 0.05). Similarly, the HOMA index was significantly greater in subjects with gallbladder EF <25% versus gallbladder EF >25% (3.3 ± 1.2 versus 2.0 ± 0.2, P < 0.05). In obese subjects (n = 66), fasting glucose, insulin, and insulin resistance were not associated with a gallbladder EF <25%. These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.

Original languageEnglish (US)
Pages (from-to)940-949
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Gallbladder
Insulin Resistance
Gallstones
Hyperlipidemias
Obesity
Volunteers
Fasting
Acalculous Cholecystitis
Glucose
Human Body
Meals
Insulin

Keywords

  • gallbladder motility
  • Insulin resistance
  • obesity

ASJC Scopus subject areas

  • Surgery

Cite this

Nakeeb, A., Comuzzie, A. G., Al-Azzawi, H., Sonnenberg, G. E., Kissebah, A. H., & Pitt, H. A. (2006). Insulin Resistance Causes Human Gallbladder Dysmotility. Journal of Gastrointestinal Surgery, 10(7), 940-949. https://doi.org/10.1016/j.gassur.2006.04.005

Insulin Resistance Causes Human Gallbladder Dysmotility. / Nakeeb, Attila; Comuzzie, Anthony G.; Al-Azzawi, Hayder; Sonnenberg, Gabriele E.; Kissebah, Ahmed H.; Pitt, Henry A.

In: Journal of Gastrointestinal Surgery, Vol. 10, No. 7, 01.07.2006, p. 940-949.

Research output: Contribution to journalArticle

Nakeeb, A, Comuzzie, AG, Al-Azzawi, H, Sonnenberg, GE, Kissebah, AH & Pitt, HA 2006, 'Insulin Resistance Causes Human Gallbladder Dysmotility', Journal of Gastrointestinal Surgery, vol. 10, no. 7, pp. 940-949. https://doi.org/10.1016/j.gassur.2006.04.005
Nakeeb A, Comuzzie AG, Al-Azzawi H, Sonnenberg GE, Kissebah AH, Pitt HA. Insulin Resistance Causes Human Gallbladder Dysmotility. Journal of Gastrointestinal Surgery. 2006 Jul 1;10(7):940-949. https://doi.org/10.1016/j.gassur.2006.04.005
Nakeeb, Attila ; Comuzzie, Anthony G. ; Al-Azzawi, Hayder ; Sonnenberg, Gabriele E. ; Kissebah, Ahmed H. ; Pitt, Henry A. / Insulin Resistance Causes Human Gallbladder Dysmotility. In: Journal of Gastrointestinal Surgery. 2006 ; Vol. 10, No. 7. pp. 940-949.
@article{c72f2ac1417e474d90e3267cd55be3bb,
title = "Insulin Resistance Causes Human Gallbladder Dysmotility",
abstract = "Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones. A growing body of animal and human data has correlated insulin resistance with organ dysfunction. The relationship among obesity, diabetes, hyperlipidemia, and abnormal gallbladder motility remains unclear. Therefore, we designed a study to investigate the association among obesity, insulin resistance, hyperlipidemia, and gallbladder dysmotility. One hundred ninety-two healthy adult nondiabetic volunteers were studied. Gallbladder ultrasounds were performed before and after a standardized fatty meal. A gallbladder ejection fraction (EF) was calculated, and an EF of <25{\%} was considered abnormal. Serum was analyzed for cholesterol, triglycerides, cholecystokinin, leptin, glucose, and insulin. The homeostasis assessment model (HOMA) was used to determine insulin resistance. The volunteers had a mean age of 38 years (range, 18-77), and 55{\%} were female. Thirty subjects (15{\%}) had gallstones and were excluded from the study. Thirty subjects (19{\%}) had abnormal gallbladder motility (EF <25{\%}). In lean subjects (n = 96) fasting glucose was significantly increased in the 16 subjects with gallbladder EF <25{\%} versus the 80 subjects with gallbladder EF >25{\%} (109 ± 20 mg/dl versus 78 ± 2 mg/dl, P < 0.05). Similarly, the HOMA index was significantly greater in subjects with gallbladder EF <25{\%} versus gallbladder EF >25{\%} (3.3 ± 1.2 versus 2.0 ± 0.2, P < 0.05). In obese subjects (n = 66), fasting glucose, insulin, and insulin resistance were not associated with a gallbladder EF <25{\%}. These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.",
keywords = "gallbladder motility, Insulin resistance, obesity",
author = "Attila Nakeeb and Comuzzie, {Anthony G.} and Hayder Al-Azzawi and Sonnenberg, {Gabriele E.} and Kissebah, {Ahmed H.} and Pitt, {Henry A.}",
year = "2006",
month = "7",
day = "1",
doi = "10.1016/j.gassur.2006.04.005",
language = "English (US)",
volume = "10",
pages = "940--949",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Insulin Resistance Causes Human Gallbladder Dysmotility

AU - Nakeeb, Attila

AU - Comuzzie, Anthony G.

AU - Al-Azzawi, Hayder

AU - Sonnenberg, Gabriele E.

AU - Kissebah, Ahmed H.

AU - Pitt, Henry A.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones. A growing body of animal and human data has correlated insulin resistance with organ dysfunction. The relationship among obesity, diabetes, hyperlipidemia, and abnormal gallbladder motility remains unclear. Therefore, we designed a study to investigate the association among obesity, insulin resistance, hyperlipidemia, and gallbladder dysmotility. One hundred ninety-two healthy adult nondiabetic volunteers were studied. Gallbladder ultrasounds were performed before and after a standardized fatty meal. A gallbladder ejection fraction (EF) was calculated, and an EF of <25% was considered abnormal. Serum was analyzed for cholesterol, triglycerides, cholecystokinin, leptin, glucose, and insulin. The homeostasis assessment model (HOMA) was used to determine insulin resistance. The volunteers had a mean age of 38 years (range, 18-77), and 55% were female. Thirty subjects (15%) had gallstones and were excluded from the study. Thirty subjects (19%) had abnormal gallbladder motility (EF <25%). In lean subjects (n = 96) fasting glucose was significantly increased in the 16 subjects with gallbladder EF <25% versus the 80 subjects with gallbladder EF >25% (109 ± 20 mg/dl versus 78 ± 2 mg/dl, P < 0.05). Similarly, the HOMA index was significantly greater in subjects with gallbladder EF <25% versus gallbladder EF >25% (3.3 ± 1.2 versus 2.0 ± 0.2, P < 0.05). In obese subjects (n = 66), fasting glucose, insulin, and insulin resistance were not associated with a gallbladder EF <25%. These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.

AB - Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones. A growing body of animal and human data has correlated insulin resistance with organ dysfunction. The relationship among obesity, diabetes, hyperlipidemia, and abnormal gallbladder motility remains unclear. Therefore, we designed a study to investigate the association among obesity, insulin resistance, hyperlipidemia, and gallbladder dysmotility. One hundred ninety-two healthy adult nondiabetic volunteers were studied. Gallbladder ultrasounds were performed before and after a standardized fatty meal. A gallbladder ejection fraction (EF) was calculated, and an EF of <25% was considered abnormal. Serum was analyzed for cholesterol, triglycerides, cholecystokinin, leptin, glucose, and insulin. The homeostasis assessment model (HOMA) was used to determine insulin resistance. The volunteers had a mean age of 38 years (range, 18-77), and 55% were female. Thirty subjects (15%) had gallstones and were excluded from the study. Thirty subjects (19%) had abnormal gallbladder motility (EF <25%). In lean subjects (n = 96) fasting glucose was significantly increased in the 16 subjects with gallbladder EF <25% versus the 80 subjects with gallbladder EF >25% (109 ± 20 mg/dl versus 78 ± 2 mg/dl, P < 0.05). Similarly, the HOMA index was significantly greater in subjects with gallbladder EF <25% versus gallbladder EF >25% (3.3 ± 1.2 versus 2.0 ± 0.2, P < 0.05). In obese subjects (n = 66), fasting glucose, insulin, and insulin resistance were not associated with a gallbladder EF <25%. These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.

KW - gallbladder motility

KW - Insulin resistance

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=33745938742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745938742&partnerID=8YFLogxK

U2 - 10.1016/j.gassur.2006.04.005

DO - 10.1016/j.gassur.2006.04.005

M3 - Article

C2 - 16843864

AN - SCOPUS:33745938742

VL - 10

SP - 940

EP - 949

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 7

ER -