Insulin resistance in the vasculature

Kieren Mather, Helmut O. Steinberg, Alain D. Baron

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It accompanies several disease states, including obesity, type 2 diabetes, hepatitis C, and polycystic ovary syndrome, and is a primary feature of metabolic syndrome. Outside of its effects on blood glucose levels, insulin resistance is also associated with a 2- to 3-fold increased risk of cardiovascular mortality. In 1996, Alain Baron, Helmut Steinberg, and colleagues demonstrated that insulin resistance is associated with endothelial dysfunction. This seminal observation led to significant advances in our understanding of insulin's action in health and disease.

Original languageEnglish
Pages (from-to)1003-1004
Number of pages2
JournalJournal of Clinical Investigation
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2013

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Insulin Resistance
Polycystic Ovary Syndrome
Hepatitis C
Muscle Cells
Type 2 Diabetes Mellitus
Blood Glucose
Skeletal Muscle
Obesity
Fats
Observation
Insulin
Glucose
Mortality
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Insulin resistance in the vasculature. / Mather, Kieren; Steinberg, Helmut O.; Baron, Alain D.

In: Journal of Clinical Investigation, Vol. 123, No. 3, 01.03.2013, p. 1003-1004.

Research output: Contribution to journalArticle

Mather, Kieren ; Steinberg, Helmut O. ; Baron, Alain D. / Insulin resistance in the vasculature. In: Journal of Clinical Investigation. 2013 ; Vol. 123, No. 3. pp. 1003-1004.
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