Insulin resistance in the vasculature

Kieren J. Mather, Helmut O. Steinberg, Alain D. Baron

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It accompanies several disease states, including obesity, type 2 diabetes, hepatitis C, and polycystic ovary syndrome, and is a primary feature of metabolic syndrome. Outside of its effects on blood glucose levels, insulin resistance is also associated with a 2- to 3-fold increased risk of cardiovascular mortality. In 1996, Alain Baron, Helmut Steinberg, and colleagues demonstrated that insulin resistance is associated with endothelial dysfunction. This seminal observation led to significant advances in our understanding of insulin's action in health and disease.

Original languageEnglish (US)
Pages (from-to)1003-1004
Number of pages2
JournalJournal of Clinical Investigation
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Mather, K. J., Steinberg, H. O., & Baron, A. D. (2013). Insulin resistance in the vasculature. Journal of Clinical Investigation, 123(3), 1003-1004. https://doi.org/10.1172/JCI67166