Insulin Resistance Is Associated with Increased Serum Levels of Glycosylphosphatidylinositol-Specific Phospholipase D

Trisha A. Kurtz, Naomi S. Fineberg, Robert V. Considine, Mark A. Deeg

Research output: Contribution to journalArticle

17 Scopus citations


The dyslipidemia of the metabolic syndrome is associated with alterations in triglyceride and high-density lipoprotein (HDL) metabolism. We examined the serum levels of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor HDL-associated protein, in a cohort with a wide range of insulin sensitivity. The mean serum GPI-PLD mass from 109 subjects was 58.9 ± 18.4 μg/mL (mean ± SD). GPI-PLD levels directly correlated with cholesterol, apolipoprotein AI, triglycerides, insulin, and homeostasis model assessment (HOMA) but not C-reactive protein. These results suggest that increased serum GPI-PLD is associated with the insulin resistance.

Original languageEnglish (US)
Pages (from-to)138-139
Number of pages2
JournalMetabolism: Clinical and Experimental
Issue number2
StatePublished - Feb 2004


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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