Insulinlike growth factor-I

Maria Grant

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Insulinlike growth factors (IGF-I and IGF-II), single-chain polypeptides structurally homologous to proinsulin, exert insulinlike metabolic effects and regulate the proliferation and differentiation of numerous cell types. IGFs are abundant in circulation and are produced under specific conditions by most tissues. The liver is the major source of circulating IGF-I, whereby growth hormone, in the presence of insulin, triggers IGF-I gene transcription. IGF-I acts in a paracrine manner in vivo to mediate many of the physiological activities of growth hormone. IGF-I action is modulated by six binding proteins (IGFBPs) that are degraded by specific IGFBP proteases.

Original languageEnglish (US)
Pages (from-to)335-345
Number of pages11
JournalCurrent Opinion in Endocrinology and Diabetes
Volume3
Issue number4
StatePublished - 1996
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor I
Fibrinogen
Intercellular Signaling Peptides and Proteins
Insulin-Like Growth Factor Binding Proteins
Growth Hormone
Proinsulin
Insulin-Like Growth Factor II
Cell Differentiation
Carrier Proteins
Peptide Hydrolases
Insulin
Peptides
Liver
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Insulinlike growth factor-I. / Grant, Maria.

In: Current Opinion in Endocrinology and Diabetes, Vol. 3, No. 4, 1996, p. 335-345.

Research output: Contribution to journalArticle

Grant, M 1996, 'Insulinlike growth factor-I', Current Opinion in Endocrinology and Diabetes, vol. 3, no. 4, pp. 335-345.
Grant, Maria. / Insulinlike growth factor-I. In: Current Opinion in Endocrinology and Diabetes. 1996 ; Vol. 3, No. 4. pp. 335-345.
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