Insulinlike Growth Factors in Patients With Active Nephrotic Syndrome

Eduardo H. Garin, Maria B. Grant, Janet H. Silverstein

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The serum concentrations of insulin-like growth factors 1 and 2 were measured by specific radioimmunoassays in 25 nephrotic patients. The serum concentration of IGF-1 in nephrotic patients was significantly lower than that observed in 20 control subjects matched for sex and age The IGF-2 serum concentration was significantly lower in nephrotic patients than in control subjects The IGF-1 and IGF-2 150-kd and 45-kd carrier protein complexes were found in the urine of nephrotic patients, whereas there was no binding of radiolabeled IGF-1 or IGF-2 to IGF carrier proteins in the urine of control subjects. The low serum IGF-1 and IGF-2 levels observed in nephrotic patients could be partially due to the increased urinary losses of the IGF carrier proteins.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume143
Issue number7
DOIs
StatePublished - Jul 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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