The serum concentrations of insulin-like growth factors 1 and 2 were measured by specific radioimmunoassays in 25 nephrotic patients. The serum concentration of IGF-1 in nephrotic patients was significantly lower than that observed in 20 control subjects matched for sex and age The IGF-2 serum concentration was significantly lower in nephrotic patients than in control subjects The IGF-1 and IGF-2 150-kd and 45-kd carrier protein complexes were found in the urine of nephrotic patients, whereas there was no binding of radiolabeled IGF-1 or IGF-2 to IGF carrier proteins in the urine of control subjects. The low serum IGF-1 and IGF-2 levels observed in nephrotic patients could be partially due to the increased urinary losses of the IGF carrier proteins.
|Original language||English (US)|
|Number of pages||3|
|Journal||American Journal of Diseases of Children|
|State||Published - Jul 1989|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health