Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota

Andrew R. Marley, Hao Fan, Margaret L. Hoyt, Kristin E. Anderson, Jianjun Zhang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background/Objectives: Folate, vitamin B6, vitamin B12, and methionine are involved in DNA synthesis and methylation and thus may modulate pancreatic cancer risk. We investigated these associations in a population-based case-control study conducted in 1994–1998. Subjects/Methods: Cases (n = 150) were identified from all hospitals in the metropolitan areas of the Twin Cities and the Mayo Clinic, Minnesota. Controls (n = 459) were selected randomly from the general population and were frequency matched to cases by age, sex, and race. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for risk of pancreatic cancer in relation to intake of nutrients considered. Results: Dietary intake of folate was associated with a reduced pancreatic cancer risk [OR (95% CI) for quartile (Q) 4 vs. Q1: 0.31 (0.12–0.78)]. A composite score (range from 2 to 8), reflecting combined dietary intake of folate and vitamin B6, was also inversely associated with pancreatic cancer risk [OR (95% CI) for Q4 vs. Q1: 0.24 (0.08–0.70)]. Null associations were found for intake of vitamin B12 and methionine. Conclusions: Dietary folate intake was associated with a reduced pancreatic cancer risk, and this association became stronger when dietary intake of folate and vitamin B6 was combined in analysis.

Original languageEnglish (US)
Pages (from-to)1128-1135
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume72
Issue number8
DOIs
StatePublished - Aug 1 2018

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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