Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women1-3

Yan Song, Nai Chieh Y. You, Yiqing Song, Mo K. Kang, Lifang Hou, Robert Wallace, Charles B. Eaton, Lesley F. Tinker, Simin Liu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Dietary factors, including dietary fat, may affect the biological aging process, as reflected by the shortening of telomere length (TL), by affecting levels of oxidative stress and inflammatory responses. We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 apparently healthy postmenopausal women who participated in the Womens Health Initiative, intakes of total fat, individual fatty acids, and fat-rich foods were assessed by a questionnaire. TL was measured by quantitative polymerase chain reaction. Intake of short-to-mediumchain saturated fatty acids (SMSFAs; aliphatic tails of #12 carbons) was inversely associated with TL. Compared with participants in other quartiles of SMSFA intake, women who were in the highest quartile (median: 1.29% of energy) had shorter TLs [mean: 4.00 kb (95% CI: 3.89, 4.11 kb)], whereas women in the lowest quartile of intake (median: 0.29% of energy) had longer TLs [mean: 4.13 kb (95% CI: 4.03, 4.24 kb); P-trend = 0.046]. Except for lauric acid, all other individual SMSFAs were inversely associated with TL (P < 0.05). In isoenergetic substitution models, the substitution of 1% of energy from SMSFAs with any other energy source was associated with 119 bp longer TLs (95% CI: 21, 216 bp). Intakes of nonskim milk, butter, and whole-milk cheese (major sources of SMSFAs) were all inversely associated with TL. No significant associations were found with long-chain saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids. In conclusion, we found that higher intakes of SMSFAs and SMSFA-rich foods were associated with shorter peripheral leukocyte TL among postmenopausal women. These findings suggest the potential roles of SMSFAs in the rate of biological aging.

Original languageEnglish (US)
Pages (from-to)907-914
Number of pages8
JournalJournal of Nutrition
Volume143
Issue number6
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

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Telomere
Leukocytes
Fatty Acids
lauric acid
Dietary Fats
Fats
Food
Milk
Telomere Shortening
Biological Phenomena
Monounsaturated Fatty Acids
Butter
Cheese
Women's Health
Unsaturated Fatty Acids
Oxidative Stress
Carbon
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women1-3 . / Song, Yan; You, Nai Chieh Y.; Song, Yiqing; Kang, Mo K.; Hou, Lifang; Wallace, Robert; Eaton, Charles B.; Tinker, Lesley F.; Liu, Simin.

In: Journal of Nutrition, Vol. 143, No. 6, 01.06.2013, p. 907-914.

Research output: Contribution to journalArticle

Song, Yan ; You, Nai Chieh Y. ; Song, Yiqing ; Kang, Mo K. ; Hou, Lifang ; Wallace, Robert ; Eaton, Charles B. ; Tinker, Lesley F. ; Liu, Simin. / Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women1-3 In: Journal of Nutrition. 2013 ; Vol. 143, No. 6. pp. 907-914.
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abstract = "Dietary factors, including dietary fat, may affect the biological aging process, as reflected by the shortening of telomere length (TL), by affecting levels of oxidative stress and inflammatory responses. We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 apparently healthy postmenopausal women who participated in the Womens Health Initiative, intakes of total fat, individual fatty acids, and fat-rich foods were assessed by a questionnaire. TL was measured by quantitative polymerase chain reaction. Intake of short-to-mediumchain saturated fatty acids (SMSFAs; aliphatic tails of #12 carbons) was inversely associated with TL. Compared with participants in other quartiles of SMSFA intake, women who were in the highest quartile (median: 1.29{\%} of energy) had shorter TLs [mean: 4.00 kb (95{\%} CI: 3.89, 4.11 kb)], whereas women in the lowest quartile of intake (median: 0.29{\%} of energy) had longer TLs [mean: 4.13 kb (95{\%} CI: 4.03, 4.24 kb); P-trend = 0.046]. Except for lauric acid, all other individual SMSFAs were inversely associated with TL (P < 0.05). In isoenergetic substitution models, the substitution of 1{\%} of energy from SMSFAs with any other energy source was associated with 119 bp longer TLs (95{\%} CI: 21, 216 bp). Intakes of nonskim milk, butter, and whole-milk cheese (major sources of SMSFAs) were all inversely associated with TL. No significant associations were found with long-chain saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids. In conclusion, we found that higher intakes of SMSFAs and SMSFA-rich foods were associated with shorter peripheral leukocyte TL among postmenopausal women. These findings suggest the potential roles of SMSFAs in the rate of biological aging.",
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T1 - Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women1-3

AU - Song, Yan

AU - You, Nai Chieh Y.

AU - Song, Yiqing

AU - Kang, Mo K.

AU - Hou, Lifang

AU - Wallace, Robert

AU - Eaton, Charles B.

AU - Tinker, Lesley F.

AU - Liu, Simin

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