Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes

Wenshuai Li, Xiangzhu Zhu, Yiqing Song, Lei Fan, Lijun Wu, Edmond K. Kabagambe, Lifang Hou, Martha J. Shrubsole, Jie Liu, Qi Dai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Obesity and insulin resistance play important roles in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency. The present study aimed to investigate whether Mg and Ca intakes were associated with risk of fatty liver disease and prediabetes by alcohol drinking status. Design: We analysed the association between Ca or Mg intake and fatty liver disease, prediabetes or both prediabetes and fatty liver disease in cross-sectional analyses. Setting: Third National Health and Nutrition Examination Survey (NHANES III) follow-up cohort of US adults. Subjects: Nationally representative sample of US adults in NHANES (n 13 489). Results: After adjusting for potential confounders, Mg intake was associated with approximately 30 % reduced odds of fatty liver disease and prediabetes, comparing the highest intake quartile v. the lowest. Mg intake may only be related to reduced odds of fatty liver disease and prediabetes in those whose Ca intake is less than 1200 mg/d. Mg intake may also only be associated with reduced odds of fatty liver disease among alcohol drinkers. Conclusions: The study suggests that high intake of Mg may be associated with reduced risks of fatty liver disease and prediabetes. Further large studies, particularly prospective cohort studies, are warranted to confirm the findings.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalPublic Health Nutrition
DOIs
StateAccepted/In press - Apr 2 2018

Fingerprint

Prediabetic State
Fatty Liver
Magnesium
Liver Diseases
Calcium
Nutrition Surveys
Insulin Resistance
Alcoholic Liver Diseases
Alcohol Drinking
Cohort Studies
Obesity
Cross-Sectional Studies
Alcohols
Prospective Studies

Keywords

  • Calcium
  • Fatty liver disease
  • Magnesium
  • Prediabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes. / Li, Wenshuai; Zhu, Xiangzhu; Song, Yiqing; Fan, Lei; Wu, Lijun; Kabagambe, Edmond K.; Hou, Lifang; Shrubsole, Martha J.; Liu, Jie; Dai, Qi.

In: Public Health Nutrition, 02.04.2018, p. 1-8.

Research output: Contribution to journalArticle

Li, W, Zhu, X, Song, Y, Fan, L, Wu, L, Kabagambe, EK, Hou, L, Shrubsole, MJ, Liu, J & Dai, Q 2018, 'Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes', Public Health Nutrition, pp. 1-8. https://doi.org/10.1017/S1368980018000642
Li, Wenshuai ; Zhu, Xiangzhu ; Song, Yiqing ; Fan, Lei ; Wu, Lijun ; Kabagambe, Edmond K. ; Hou, Lifang ; Shrubsole, Martha J. ; Liu, Jie ; Dai, Qi. / Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes. In: Public Health Nutrition. 2018 ; pp. 1-8.
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