Integrated analysis of competing endogenous RNA network revealing lncRNAs as potential prognostic biomarkers in human lung squamous cell carcinoma

Jing Sui, Si Yi Xu, Jiali Han, Song Ru Yang, Cheng Yun Li, Li Hong Yin, Yue Pu Pu, Ge Yu Liang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Accumulating evidence shows the important role of long non-coding RNAs (lncRNAs) in competing endogenous RNA (ceRNA) networks for predicting survival in tumor patients. However, prognostic biomarkers for lung squamous cell carcinoma (LUSC) are still lacking. The objective of this study is to identify a lncRNA signature for evaluation of overall survival (OS) in 474 LUSC patients from The Cancer Genome Atlas (TCGA) database. A total of 474 RNA sequencing profiles in LUSC patients with clinical data were obtained, providing a large sample of RNA sequencing data, and 83 LUSC-specific lncRNAs, 26 miRNAs, and 85 mRNAs were identified to construct the ceRNA network (fold change > 2, P < 0.05). Among these above 83 LUSC-specific lncRNAs, 22 were assessed as closely related to OS in LUSC patients using a univariate Cox proportional regression model. Meanwhile, two (FMO6P and PRR26) of the above 22 OS-related lncRNAs were identified using a multivariate Cox regression model to construct a risk score as an independent indicator of the prognostic value of the lncRNA signature in LUSC patients. LUSC patients with low-risk scores were more positively correlated with OS (P < 0.001). The present study provides a deeper understanding of the lncRNA-related ceRNA network in LUSC and suggests that the two-lncRNA signature could serve as an independent biomarker for prognosis of LUSC.

Original languageEnglish (US)
Pages (from-to)65997-66018
Number of pages22
JournalOncotarget
Volume8
Issue number39
DOIs
StatePublished - Jan 1 2017

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Long Noncoding RNA
Squamous Cell Carcinoma
Biomarkers
RNA
Lung
Survival
RNA Sequence Analysis
Atlases
MicroRNAs
Proportional Hazards Models
Neoplasms

Keywords

  • CeRNA network
  • LncRNA
  • LUSC
  • Prognostic biomarker

ASJC Scopus subject areas

  • Oncology

Cite this

Integrated analysis of competing endogenous RNA network revealing lncRNAs as potential prognostic biomarkers in human lung squamous cell carcinoma. / Sui, Jing; Xu, Si Yi; Han, Jiali; Yang, Song Ru; Li, Cheng Yun; Yin, Li Hong; Pu, Yue Pu; Liang, Ge Yu.

In: Oncotarget, Vol. 8, No. 39, 01.01.2017, p. 65997-66018.

Research output: Contribution to journalArticle

Sui, Jing ; Xu, Si Yi ; Han, Jiali ; Yang, Song Ru ; Li, Cheng Yun ; Yin, Li Hong ; Pu, Yue Pu ; Liang, Ge Yu. / Integrated analysis of competing endogenous RNA network revealing lncRNAs as potential prognostic biomarkers in human lung squamous cell carcinoma. In: Oncotarget. 2017 ; Vol. 8, No. 39. pp. 65997-66018.
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