Integrated sensing and delivery of oxygen for next-generation smart wound dressings

Manuel Ochoa, Rahim Rahimi, Jiawei Zhou, Hongjie Jiang, Chang Keun Yoon, Dinesh Maddipatla, Binu Baby Narakathu, Vaibhav Jain, Mark Michael Oscai, Thaddeus Joseph Morken, Rebeca Hannah Oliveira, Gonzalo L. Campana, Oscar W. Cummings, Michael A. Zieger, Rajiv Sood, Massood Z. Atashbar, Babak Ziaie

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat. Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors, but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform. Thus, we developed a low-cost alternative for continuous O2 delivery and sensing comprising of an inexpensive, paper-based, biocompatible, flexible platform for locally generating and measuring oxygen in a wound region. The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology, inkjet printing. Here, we demonstrate the functionality of the oxygenation patch, capable of increasing oxygen concentration in a gel substrate by 13% (5 ppm) in 1 h. The platform is able to sense oxygen in a range of 5–26 ppm. In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

Original languageEnglish (US)
Article number46
JournalMicrosystems and Nanoengineering
Volume6
Issue number1
DOIs
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Materials Science (miscellaneous)
  • Condensed Matter Physics
  • Industrial and Manufacturing Engineering
  • Electrical and Electronic Engineering

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