Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach

Angela Fago, Frank B. Jensen, Bruno Tota, Martin Feelisch, Kenneth Olson, Signe Helbo, Sjannie Lefevre, Daniele Mancardi, Anna Palumbo, Guro K. Sandvik, Nini Skovgaard

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Hydrogen sulfide (H 2S), nitric oxide (NO) and nitrite (NO 2 -) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H 2S in the whole-body responses to hypoxia.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume162
Issue number1
DOIs
StatePublished - May 2012

Fingerprint

Physiological Adaptation
Hydrogen Sulfide
Nitrites
Nitric Oxide
Cardiovascular system
Cytoprotection
Cardiovascular System
Blood Vessels
Animals
Tissue
Molecules
Hypoxia

Keywords

  • Cytoprotection
  • Gasotransmitter
  • Oxygen sensing
  • S-nitrosothiols
  • Vasoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Physiology

Cite this

Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia : A comparative approach. / Fago, Angela; Jensen, Frank B.; Tota, Bruno; Feelisch, Martin; Olson, Kenneth; Helbo, Signe; Lefevre, Sjannie; Mancardi, Daniele; Palumbo, Anna; Sandvik, Guro K.; Skovgaard, Nini.

In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 162, No. 1, 05.2012, p. 1-6.

Research output: Contribution to journalArticle

Fago, Angela ; Jensen, Frank B. ; Tota, Bruno ; Feelisch, Martin ; Olson, Kenneth ; Helbo, Signe ; Lefevre, Sjannie ; Mancardi, Daniele ; Palumbo, Anna ; Sandvik, Guro K. ; Skovgaard, Nini. / Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia : A comparative approach. In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 2012 ; Vol. 162, No. 1. pp. 1-6.
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