Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach

Angela Fago, Frank B. Jensen, Bruno Tota, Martin Feelisch, Kenneth R. Olson, Signe Helbo, Sjannie Lefevre, Daniele Mancardi, Anna Palumbo, Guro K. Sandvik, Nini Skovgaard

Research output: Contribution to journalReview article

29 Scopus citations


Hydrogen sulfide (H 2S), nitric oxide (NO) and nitrite (NO 2 -) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H 2S in the whole-body responses to hypoxia.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Issue number1
StatePublished - May 2012



  • Cytoprotection
  • Gasotransmitter
  • Oxygen sensing
  • S-nitrosothiols
  • Vasoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Physiology

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