Integration of surgery and systemic therapy

Results and principles of integration

J. P. Donohue, I. Leviovitch, Richard Foster, J. Baniel, P. Tognoni

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5%) had one or more of these risk factors, 67.5% are long-term survivors following PC- RPLND. The remaining 47.5% were referred after primary chemotherapy, without risk factors. Only 9.8% relapsed end 95.5% survived.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalSeminars in Urologic Oncology
Volume16
Issue number2
StatePublished - 1998

Fingerprint

Lymph Node Excision
Drug Therapy
Germ Cell and Embryonal Neoplasms
Residual Neoplasm
Tumor Biomarkers
Survivors
Therapeutics
Recurrence
Survival

ASJC Scopus subject areas

  • Urology

Cite this

Donohue, J. P., Leviovitch, I., Foster, R., Baniel, J., & Tognoni, P. (1998). Integration of surgery and systemic therapy: Results and principles of integration. Seminars in Urologic Oncology, 16(2), 65-71.

Integration of surgery and systemic therapy : Results and principles of integration. / Donohue, J. P.; Leviovitch, I.; Foster, Richard; Baniel, J.; Tognoni, P.

In: Seminars in Urologic Oncology, Vol. 16, No. 2, 1998, p. 65-71.

Research output: Contribution to journalArticle

Donohue, JP, Leviovitch, I, Foster, R, Baniel, J & Tognoni, P 1998, 'Integration of surgery and systemic therapy: Results and principles of integration', Seminars in Urologic Oncology, vol. 16, no. 2, pp. 65-71.
Donohue, J. P. ; Leviovitch, I. ; Foster, Richard ; Baniel, J. ; Tognoni, P. / Integration of surgery and systemic therapy : Results and principles of integration. In: Seminars in Urologic Oncology. 1998 ; Vol. 16, No. 2. pp. 65-71.
@article{a2b93856158d4d318b3d802ef595ba6a,
title = "Integration of surgery and systemic therapy: Results and principles of integration",
abstract = "Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5{\%}) had one or more of these risk factors, 67.5{\%} are long-term survivors following PC- RPLND. The remaining 47.5{\%} were referred after primary chemotherapy, without risk factors. Only 9.8{\%} relapsed end 95.5{\%} survived.",
author = "Donohue, {J. P.} and I. Leviovitch and Richard Foster and J. Baniel and P. Tognoni",
year = "1998",
language = "English",
volume = "16",
pages = "65--71",
journal = "Urologic Oncology",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Integration of surgery and systemic therapy

T2 - Results and principles of integration

AU - Donohue, J. P.

AU - Leviovitch, I.

AU - Foster, Richard

AU - Baniel, J.

AU - Tognoni, P.

PY - 1998

Y1 - 1998

N2 - Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5%) had one or more of these risk factors, 67.5% are long-term survivors following PC- RPLND. The remaining 47.5% were referred after primary chemotherapy, without risk factors. Only 9.8% relapsed end 95.5% survived.

AB - Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5%) had one or more of these risk factors, 67.5% are long-term survivors following PC- RPLND. The remaining 47.5% were referred after primary chemotherapy, without risk factors. Only 9.8% relapsed end 95.5% survived.

UR - http://www.scopus.com/inward/record.url?scp=0031835512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031835512&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 65

EP - 71

JO - Urologic Oncology

JF - Urologic Oncology

SN - 1078-1439

IS - 2

ER -