Integration of surgery and systemic therapy: Results and principles of integration

92 Scopus citations


Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5%) had one or more of these risk factors, 67.5% are long-term survivors following PC- RPLND. The remaining 47.5% were referred after primary chemotherapy, without risk factors. Only 9.8% relapsed end 95.5% survived.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalSeminars in Urologic Oncology
Issue number2
StatePublished - Jun 22 1998

ASJC Scopus subject areas

  • Urology

Cite this

Integration of surgery and systemic therapy : Results and principles of integration. / Donohue, J. P.; Leviovitch, I.; Foster, R. S.; Baniel, J.; Tognoni, P.

In: Seminars in Urologic Oncology, Vol. 16, No. 2, 22.06.1998, p. 65-71.

Research output: Contribution to journalReview article