Integration of surgery and systemic therapy: Results and principles of integration

J. P. Donohue, I. Leviovitch, R. S. Foster, J. Baniel, P. Tognoni

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Eight hundred seventy patients with metastatic nonseminomatous germ cell cancer underwent postchemotherapy retroperitoneal lymph node dissection (PC- RPLND) for resection of residual disease. Several risk factors for relapse and survival were identified as highly significant (P = .00001), namely, presence of residual cancer in the specimen before salvage chemotherapy programs, tumor marker elevation, need for 're-do' PC-RPLND, or unresectability. Although more than half of the entire group (52.5%) had one or more of these risk factors, 67.5% are long-term survivors following PC- RPLND. The remaining 47.5% were referred after primary chemotherapy, without risk factors. Only 9.8% relapsed end 95.5% survived.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalSeminars in Urologic Oncology
Issue number2
StatePublished - Jun 22 1998

ASJC Scopus subject areas

  • Urology

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