Intensified effect of adiposity on blood pressure in overweight and obese children

Wanzhu Tu, George J. Eckert, Linda DiMeglio, Zhangsheng Yu, Jeesun Jung, J. Howard Pratt

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

In children, blood pressure (BP) and risk for hypertension are proportional to degree of adiposity. Whether the relationship to BP is similar over the full range of adiposity is less clear. Subjects from a cohort study (n=1111; 50% male and 42% black) contributed 9102 semiannual BP and height/weight assessments. The mean enrollment age was 10.2 years, and mean follow-up was 4.5 years. Adiposity was expressed as body mass index percentile, which accounted for effects of age and sex. The following observations were made. The effect of relative adiposity on BP was minimal until the body mass index percentile reached 85, beginning of the overweight category, at which point the effect of adiposity on BP increased by 4-fold. Similarly intensified adiposity effects on BP were observed in children aged ≤10, 11 to 14 years, and ≥15 years. Serum levels of the adipose tissue-derived hormone, leptin, together with heart rate, showed an almost identically patterned relation to BP to that of body mass index percentile and BP, thus implicating a possible mediating role for leptin. In conclusion, there is a marked intensification of the influence of adiposity on BP when children reach the categories of overweight and obese. Among the possible pathways, leptin may be a potentially important mediator acting through the sympathetic nervous system (reflected in heart rate). The findings have relevance to interventions designed to prevent or treat adiposity-related increases in BP and to the analytic approaches used in epidemiological studies.

Original languageEnglish
Pages (from-to)818-824
Number of pages7
JournalHypertension
Volume58
Issue number5
DOIs
StatePublished - Nov 2011

Fingerprint

Adiposity
Blood Pressure
Leptin
Body Mass Index
Heart Rate
Sympathetic Nervous System
Adipose Tissue
Epidemiologic Studies
Cohort Studies
Hormones
Hypertension
Weights and Measures

Keywords

  • Heart rate
  • Hypertension
  • Leptin
  • Obesity
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Intensified effect of adiposity on blood pressure in overweight and obese children. / Tu, Wanzhu; Eckert, George J.; DiMeglio, Linda; Yu, Zhangsheng; Jung, Jeesun; Pratt, J. Howard.

In: Hypertension, Vol. 58, No. 5, 11.2011, p. 818-824.

Research output: Contribution to journalArticle

Tu, Wanzhu ; Eckert, George J. ; DiMeglio, Linda ; Yu, Zhangsheng ; Jung, Jeesun ; Pratt, J. Howard. / Intensified effect of adiposity on blood pressure in overweight and obese children. In: Hypertension. 2011 ; Vol. 58, No. 5. pp. 818-824.
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