Inter-test reproducibility of the lung clearance index measured by multiple breath washout

Esther Oude Engberink, Felix Ratjen, Stephanie Davis, George Retsch-Bogart, Reshma Amin, Sanja Stanojevic

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The lung clearance index (LCI) has strong intra-test repeatability; however, the inter-test reproducibility of the LCI is poorly defined. The aim of the present study was to define a physiologically meaningful change in LCI in preschool children, which discriminates changes associated with disease progression from biological variability. Repeated LCI measurements from a longitudinal cohort study of children with cystic fibrosis and age-matched controls were collected to define the inter-visit reproducibility of the LCI. Absolute change, the coefficient of variation, Bland-Altman limits of agreement, the coefficient of repeatability, intra-class correlation coefficient, and percentage changes were calculated. LCI measurements (n=505) from 71 healthy and 77 cystic fibrosis participants (aged 2.6-6 years) were analysed. LCI variability was proportional to its magnitude, such that reproducibility defined by absolute changes is biased. A physiologically relevant change for quarterly LCI measurements in health was defined as exceeding ±15%. In clinically stable cystic fibrosis participants, the threshold was higher (±25%); however, for measurements made 24 h apart, the threshold was similar to that observed in health (±17%). A percentage change in LCI greater than ±15% in preschool children can be considered physiologically relevant and greater than the biological variability of the test.

Original languageEnglish (US)
Article number1700433
JournalEuropean Respiratory Journal
Volume50
Issue number4
DOIs
StatePublished - Oct 1 2017

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Lung
Cystic Fibrosis
Preschool Children
Health
Longitudinal Studies
Disease Progression
Cohort Studies

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Inter-test reproducibility of the lung clearance index measured by multiple breath washout. / Oude Engberink, Esther; Ratjen, Felix; Davis, Stephanie; Retsch-Bogart, George; Amin, Reshma; Stanojevic, Sanja.

In: European Respiratory Journal, Vol. 50, No. 4, 1700433, 01.10.2017.

Research output: Contribution to journalArticle

Oude Engberink, Esther ; Ratjen, Felix ; Davis, Stephanie ; Retsch-Bogart, George ; Amin, Reshma ; Stanojevic, Sanja. / Inter-test reproducibility of the lung clearance index measured by multiple breath washout. In: European Respiratory Journal. 2017 ; Vol. 50, No. 4.
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