Interaction of ouabain and propranolol in the central nervous system. Neurally-mediated effects on the cardiovascular system

Subbiah Sivam, S. D. Seth, U. Nayar, S. C. Manchanda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of intracerebroventricular (i.c.v.) ouabain alone and after pretreatment with i.c.v. (±)-propranolol, (+)-propranolol, UM-272 (a quaternary analogue of propranolol) and lignocaine, on arterial blood pressure (BP), heart rate (HR) and cardiac rhythm was investigated in chloralose anesthetized, vagotomized cats. Ouabain elicited an increase in BP and HR followed by cardiac arrhythmias of ventricular origin. Pretreatment with (±)-propranolol, (+)-propranolol or UM-272 attenuated/prevented the cardiovascular effects of ouabain whereas lignocaine did not modify the response appreciably. Since UM-272, which lacks local anesthetic activity and β-blocking activity also shared the antagonism with (±)- and (+)-propranolo, it is deduced that neither β-blocking nor local anesthetic activity of propranolol could be responsible for this antagonism. This is supported by the fact that lignocaine which has a comparable local anesthetic effect of propranolol failed to modify significantly the cardiovascular response to ouabain. The antagonism appears to be a direct neural depressant effect independent of local anesthetic action. The neural depressant effect may be due to an interference in depolarization process and/or a neurone-blocking effect.

Original languageEnglish (US)
Pages (from-to)286-293
Number of pages8
JournalPharmacology
Volume25
Issue number5
StatePublished - 1982
Externally publishedYes

Fingerprint

Ouabain
Cardiovascular System
Propranolol
Central Nervous System
Local Anesthetics
Lidocaine
Heart Rate
Chloralose
Anesthetics
Cardiac Arrhythmias
Arterial Pressure
Cats
Blood Pressure
Neurons
pranolium

ASJC Scopus subject areas

  • Pharmacology

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Interaction of ouabain and propranolol in the central nervous system. Neurally-mediated effects on the cardiovascular system. / Sivam, Subbiah; Seth, S. D.; Nayar, U.; Manchanda, S. C.

In: Pharmacology, Vol. 25, No. 5, 1982, p. 286-293.

Research output: Contribution to journalArticle

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