Interaction of Rifampin and Glucocorticoids: Adverse Effect on Renal Allograft Function

Gary A. Buffington, Jesus Dominguez, Walter F. Piering, Lee A. Hebert, H. Myron Kauffman, Jacob Lemann

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Three renal transplant patients experienced progressive loss of renal allograft function during rifampin treatment for Mycobacterium tuberculosis. Previous studies have shown that rifampin causes induction of enzymes in hepatic microsomes that increase the catabolism of glucocorticoids. Evidence is presented that in our patients, the loss of renal allograft function during rifampin therapy was the result of decreased glucocorticoid effect presumably related to increased catabolism of the glucocorticoid drug they received. Thus, the adverse effects of rifampin on renal transplant function might be overcome by increasing the dose of glucocorticoid drug.

Original languageEnglish (US)
Pages (from-to)1958-1960
Number of pages3
JournalJournal of the American Medical Association
Volume236
Issue number17
DOIs
StatePublished - Oct 25 1976
Externally publishedYes

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Rifampin
Glucocorticoids
Allografts
Kidney
Transplants
Enzyme Induction
Microsomes
Mycobacterium tuberculosis
Pharmaceutical Preparations
Liver
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Interaction of Rifampin and Glucocorticoids : Adverse Effect on Renal Allograft Function. / Buffington, Gary A.; Dominguez, Jesus; Piering, Walter F.; Hebert, Lee A.; Kauffman, H. Myron; Lemann, Jacob.

In: Journal of the American Medical Association, Vol. 236, No. 17, 25.10.1976, p. 1958-1960.

Research output: Contribution to journalArticle

Buffington, Gary A. ; Dominguez, Jesus ; Piering, Walter F. ; Hebert, Lee A. ; Kauffman, H. Myron ; Lemann, Jacob. / Interaction of Rifampin and Glucocorticoids : Adverse Effect on Renal Allograft Function. In: Journal of the American Medical Association. 1976 ; Vol. 236, No. 17. pp. 1958-1960.
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