Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53

H. Zimmermann, C. H. Koh, R. Degenkolbe, M. J. O'Connor, A. Muller, G. Steger, J. J. Chen, Y. Lui, E. Androphy, H. U. Bernard

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36 Scopus citations

Abstract

The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6-CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300.

Original languageEnglish (US)
Pages (from-to)2617-2623
Number of pages7
JournalJournal of General Virology
Volume81
Issue number11
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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    Zimmermann, H., Koh, C. H., Degenkolbe, R., O'Connor, M. J., Muller, A., Steger, G., Chen, J. J., Lui, Y., Androphy, E., & Bernard, H. U. (2000). Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53. Journal of General Virology, 81(11), 2617-2623. https://doi.org/10.1099/0022-1317-81-11-2617