Interactions between methamphetamine and environmental stress

Role of oxidative stress, glutamate and mitochondrial dysfunction

Despina A. Tata, Bryan Yamamoto

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Aims: Methamphetamine is an amphetamine derivative that is abused increasingly world-wide at an alarming rate over the last decade. Pre-clinical and human studies have shown that methamphetamine is neurotoxic to brain dopamine and serotonin. Other lines of study indicate that stress enhances the vulnerability to drug abuse. The purpose of this review is to shed light on the biochemical similarities between methamphetamine and stress in an effort to highlight the possibility that prior exposure to stress may interact with methamphetamine to exacerbate neurotoxicity. Methods: A review of the literature on methamphetamine and stress was conducted that focused on the common neurotoxic and biochemical consequences of methamphetamine administration and stress exposure. Results: Experimental findings of a large number of studies suggest that there are parallels between stress and methamphetamine with regard to their ability to increase glutamate release, produce a metabolic compromise and cause oxidative damage. Conclusion: A combination of methamphetamine administration and stress can act synergistically and/or additively to cause or augment toxicity in brain regions such as striatum and hippocampus.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalAddiction
Volume102
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Methamphetamine
Glutamic Acid
Oxidative Stress
Aptitude
Brain
Amphetamine
Substance-Related Disorders
Hippocampus
Dopamine
Serotonin

Keywords

  • Amphetamine
  • Dopamine
  • Drugs of abuse
  • Glucocorticoids
  • Neurotoxicity

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Interactions between methamphetamine and environmental stress : Role of oxidative stress, glutamate and mitochondrial dysfunction. / Tata, Despina A.; Yamamoto, Bryan.

In: Addiction, Vol. 102, No. SUPPL. 1, 04.2007, p. 49-60.

Research output: Contribution to journalReview article

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