Interactions of colony stimulating factors, other modulating cytokines and hematopoietic progenitor cells. Laboratory and clinical studies

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Abstract

Blood cell production is regulated by a complex interacting network of stem and progenitor cells, from which all the blood forming elements are derived, and the effects of cytokines which can up- or down-modulate proliferation or self-renewal of stem and progenitor cells (1,2). This report reviews in brief recent information on the characteristics of human umbilical cord blood progenitor cells, the effects of the potent co-stimulating molecule, steel factor, and the myelosuppressive effects of macrophage inflammatory protein 1α and other members of this latter group of molecules termed cytokines. In vitro as well as preclinical and clinical in vivo effects are covered.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalLeukemia
Volume6
Issue numberSUPPL. 4
StatePublished - 1992

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Colony-Stimulating Factors
Hematopoietic Stem Cells
Stem Cells
Cytokines
Blood Cells
Macrophage Inflammatory Proteins
Stem Cell Factor
Fetal Blood
Clinical Studies

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

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abstract = "Blood cell production is regulated by a complex interacting network of stem and progenitor cells, from which all the blood forming elements are derived, and the effects of cytokines which can up- or down-modulate proliferation or self-renewal of stem and progenitor cells (1,2). This report reviews in brief recent information on the characteristics of human umbilical cord blood progenitor cells, the effects of the potent co-stimulating molecule, steel factor, and the myelosuppressive effects of macrophage inflammatory protein 1α and other members of this latter group of molecules termed cytokines. In vitro as well as preclinical and clinical in vivo effects are covered.",
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