Interactions of endothelin and insulin

Expanding parameters of insulin resistance

Andrew B. Strawbridge, Jeffrey Elmendorf, Kieren Mather

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Since the discovery of endothelin peptides in the mid-1980s by Yanigasawa and colleagues, accumulating evidence demonstrates that these peptides may function beyond vasoconstriction. Strong epidemiologic associations between insulin resistance and increased endothelin levels or activity have been found, and these associations have prompted studies investigating the interactions of endothelin with insulin. In this review we explore the evidence for such interactions at multiple levels of physiology, ranging from effects on tissue perfusion through modulation of vascular tone to subcellular interactions of endothelin signaling with insulin signaling. The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalCurrent Diabetes Reviews
Volume2
Issue number3
DOIs
StatePublished - Aug 2006

Fingerprint

Endothelins
Insulin Resistance
Insulin
Blood Vessels
Peptides
Vasoconstriction
Perfusion

Keywords

  • Endothelin
  • Endothelium
  • Insulin
  • Perfusion
  • Signaling

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Interactions of endothelin and insulin : Expanding parameters of insulin resistance. / Strawbridge, Andrew B.; Elmendorf, Jeffrey; Mather, Kieren.

In: Current Diabetes Reviews, Vol. 2, No. 3, 08.2006, p. 317-327.

Research output: Contribution to journalArticle

@article{4026629967984da1b918ca48867c3d60,
title = "Interactions of endothelin and insulin: Expanding parameters of insulin resistance",
abstract = "Since the discovery of endothelin peptides in the mid-1980s by Yanigasawa and colleagues, accumulating evidence demonstrates that these peptides may function beyond vasoconstriction. Strong epidemiologic associations between insulin resistance and increased endothelin levels or activity have been found, and these associations have prompted studies investigating the interactions of endothelin with insulin. In this review we explore the evidence for such interactions at multiple levels of physiology, ranging from effects on tissue perfusion through modulation of vascular tone to subcellular interactions of endothelin signaling with insulin signaling. The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed.",
keywords = "Endothelin, Endothelium, Insulin, Perfusion, Signaling",
author = "Strawbridge, {Andrew B.} and Jeffrey Elmendorf and Kieren Mather",
year = "2006",
month = "8",
doi = "10.2174/157339906777950642",
language = "English",
volume = "2",
pages = "317--327",
journal = "Current Diabetes Reviews",
issn = "1573-3998",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Interactions of endothelin and insulin

T2 - Expanding parameters of insulin resistance

AU - Strawbridge, Andrew B.

AU - Elmendorf, Jeffrey

AU - Mather, Kieren

PY - 2006/8

Y1 - 2006/8

N2 - Since the discovery of endothelin peptides in the mid-1980s by Yanigasawa and colleagues, accumulating evidence demonstrates that these peptides may function beyond vasoconstriction. Strong epidemiologic associations between insulin resistance and increased endothelin levels or activity have been found, and these associations have prompted studies investigating the interactions of endothelin with insulin. In this review we explore the evidence for such interactions at multiple levels of physiology, ranging from effects on tissue perfusion through modulation of vascular tone to subcellular interactions of endothelin signaling with insulin signaling. The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed.

AB - Since the discovery of endothelin peptides in the mid-1980s by Yanigasawa and colleagues, accumulating evidence demonstrates that these peptides may function beyond vasoconstriction. Strong epidemiologic associations between insulin resistance and increased endothelin levels or activity have been found, and these associations have prompted studies investigating the interactions of endothelin with insulin. In this review we explore the evidence for such interactions at multiple levels of physiology, ranging from effects on tissue perfusion through modulation of vascular tone to subcellular interactions of endothelin signaling with insulin signaling. The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed.

KW - Endothelin

KW - Endothelium

KW - Insulin

KW - Perfusion

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=33746930311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746930311&partnerID=8YFLogxK

U2 - 10.2174/157339906777950642

DO - 10.2174/157339906777950642

M3 - Article

VL - 2

SP - 317

EP - 327

JO - Current Diabetes Reviews

JF - Current Diabetes Reviews

SN - 1573-3998

IS - 3

ER -