Interferon-γ in endocervical secretions of women infected with chlamydia trachomatis

Janet N. Arno, Veronica A. Ricker, Byron E. Batteiger, Barry P. Katz, Virginia A. Caine, Robert B. Jones

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Although interferon-γ has been associated with control of chlamydial infections in mice, no direct evidence links it to human chlamydial infections. Therefore, interferon-γ was assayed by ELISA in endocervical secretions and plasma of women cultured for Chlamydia tracnomatis. Women with positive endocervical chlamydial cultures had increased levels of mterferon-y in endocervical secretions (6.7 ± 2.8, mean ± SE, n = 47) compared with uninfected women (1.4 ± 0.4, n = 52) (P =.002). Interferon was also present in secretions of women with gonorrhea. Higher levels were seen in secretions from older women with positive chlamydial cultures. Interferon levels in secretions did not correlate with simultaneous plasma levels, the number of organisms recovered in tissue culture, or clinical correlates of inflammation. These data suggest that interferon-γ is present at the site of chlamydial infection; however, further experiments are needed to determine whether interferon is specifically involved in protection or is a nonspecific indicator of inflammation.

Original languageEnglish (US)
Pages (from-to)1385-1389
Number of pages5
JournalJournal of Infectious Diseases
Volume162
Issue number6
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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