Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

G. Roberts, W. Wen, A. Frankland, T. Perich, E. Holmes-Preston, F. Levy, R. K. Lenroot, D. Hadzi-Pavlovic, John Nurnberger, M. Breakspear, P. B. Mitchell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. Method WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years. Results This young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants. Conclusions Our findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD - a group at particular risk of future hypo/manic episodes - suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

Original languageEnglish (US)
Pages (from-to)2385-2396
Number of pages12
JournalPsychological Medicine
Volume46
Issue number11
DOIs
StatePublished - Aug 1 2016

Fingerprint

Bipolar Disorder
Corpus Callosum
Major Depressive Disorder
Anisotropy
White Matter
Age of Onset

Keywords

  • Bipolar disorder
  • diffusion tensor imaging
  • fractional anisotropy
  • genetic risk
  • tract-based spatial statistics

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Roberts, G., Wen, W., Frankland, A., Perich, T., Holmes-Preston, E., Levy, F., ... Mitchell, P. B. (2016). Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk. Psychological Medicine, 46(11), 2385-2396. https://doi.org/10.1017/S0033291716001161

Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk. / Roberts, G.; Wen, W.; Frankland, A.; Perich, T.; Holmes-Preston, E.; Levy, F.; Lenroot, R. K.; Hadzi-Pavlovic, D.; Nurnberger, John; Breakspear, M.; Mitchell, P. B.

In: Psychological Medicine, Vol. 46, No. 11, 01.08.2016, p. 2385-2396.

Research output: Contribution to journalArticle

Roberts, G, Wen, W, Frankland, A, Perich, T, Holmes-Preston, E, Levy, F, Lenroot, RK, Hadzi-Pavlovic, D, Nurnberger, J, Breakspear, M & Mitchell, PB 2016, 'Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk', Psychological Medicine, vol. 46, no. 11, pp. 2385-2396. https://doi.org/10.1017/S0033291716001161
Roberts, G. ; Wen, W. ; Frankland, A. ; Perich, T. ; Holmes-Preston, E. ; Levy, F. ; Lenroot, R. K. ; Hadzi-Pavlovic, D. ; Nurnberger, John ; Breakspear, M. ; Mitchell, P. B. / Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk. In: Psychological Medicine. 2016 ; Vol. 46, No. 11. pp. 2385-2396.
@article{55671f65bb0e443fb5db9dbc683c439a,
title = "Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk",
abstract = "Background White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. Method WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years. Results This young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants. Conclusions Our findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD - a group at particular risk of future hypo/manic episodes - suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.",
keywords = "Bipolar disorder, diffusion tensor imaging, fractional anisotropy, genetic risk, tract-based spatial statistics",
author = "G. Roberts and W. Wen and A. Frankland and T. Perich and E. Holmes-Preston and F. Levy and Lenroot, {R. K.} and D. Hadzi-Pavlovic and John Nurnberger and M. Breakspear and Mitchell, {P. B.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1017/S0033291716001161",
language = "English (US)",
volume = "46",
pages = "2385--2396",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "11",

}

TY - JOUR

T1 - Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

AU - Roberts, G.

AU - Wen, W.

AU - Frankland, A.

AU - Perich, T.

AU - Holmes-Preston, E.

AU - Levy, F.

AU - Lenroot, R. K.

AU - Hadzi-Pavlovic, D.

AU - Nurnberger, John

AU - Breakspear, M.

AU - Mitchell, P. B.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. Method WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years. Results This young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants. Conclusions Our findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD - a group at particular risk of future hypo/manic episodes - suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

AB - Background White matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset. Method WM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years. Results This young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants. Conclusions Our findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD - a group at particular risk of future hypo/manic episodes - suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

KW - Bipolar disorder

KW - diffusion tensor imaging

KW - fractional anisotropy

KW - genetic risk

KW - tract-based spatial statistics

UR - http://www.scopus.com/inward/record.url?scp=84976531532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976531532&partnerID=8YFLogxK

U2 - 10.1017/S0033291716001161

DO - 10.1017/S0033291716001161

M3 - Article

C2 - 27291060

AN - SCOPUS:84976531532

VL - 46

SP - 2385

EP - 2396

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 11

ER -