Interlaboratory variability of bilirubin measurements

Hendrik J. Vreman, Joel Verter, William Oh, Avroy A. Fanaroff, Linda L. Wright, James A. Lemons, Seetha Shankaran, Jon E. Tyson, Sheldon B. Korones, Charles R. Bauer, Barbara J. Stoll, Lu Ann Papile, Edward F. Donovan, Richard A. Ehrenkranz, David K. Stevenson, Ronald L. Poland, Maureen Hack, Nancy Newman, Reginald C. Tsang, Marci MersmannGeorge W. Brumley, Cathy H. Goulding, Joel Verier, Amalia Levy, Lisa Mele, Scott Denne, Diana Appel, Emmalee S. Bandstra, Amy Worth, Sumner J. Yaffe, Charlotte Catz, Linda Wright, Conra Backstrom, David K. Stevenson, Bethany Ball, Henrietta Bada, Tina Hudson, Kathleen Kennedy, Sherry Warner, Enrique Ostrea, Gerry Muran, Barbara Stonestreet, Angelita Hensman, Steven Peterec, Patricia Gettner

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

Original languageEnglish
Pages (from-to)869-873
Number of pages5
JournalClinical Chemistry
Volume42
Issue number6 SUPPL.
StatePublished - 1996

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Bilirubin

Keywords

  • Automated analysis
  • Control material
  • Quality control

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Vreman, H. J., Verter, J., Oh, W., Fanaroff, A. A., Wright, L. L., Lemons, J. A., ... Gettner, P. (1996). Interlaboratory variability of bilirubin measurements. Clinical Chemistry, 42(6 SUPPL.), 869-873.

Interlaboratory variability of bilirubin measurements. / Vreman, Hendrik J.; Verter, Joel; Oh, William; Fanaroff, Avroy A.; Wright, Linda L.; Lemons, James A.; Shankaran, Seetha; Tyson, Jon E.; Korones, Sheldon B.; Bauer, Charles R.; Stoll, Barbara J.; Papile, Lu Ann; Donovan, Edward F.; Ehrenkranz, Richard A.; Stevenson, David K.; Poland, Ronald L.; Hack, Maureen; Newman, Nancy; Tsang, Reginald C.; Mersmann, Marci; Brumley, George W.; Goulding, Cathy H.; Verier, Joel; Levy, Amalia; Mele, Lisa; Denne, Scott; Appel, Diana; Bandstra, Emmalee S.; Worth, Amy; Yaffe, Sumner J.; Catz, Charlotte; Wright, Linda; Backstrom, Conra; Stevenson, David K.; Ball, Bethany; Bada, Henrietta; Hudson, Tina; Kennedy, Kathleen; Warner, Sherry; Ostrea, Enrique; Muran, Gerry; Stonestreet, Barbara; Hensman, Angelita; Peterec, Steven; Gettner, Patricia.

In: Clinical Chemistry, Vol. 42, No. 6 SUPPL., 1996, p. 869-873.

Research output: Contribution to journalArticle

Vreman, HJ, Verter, J, Oh, W, Fanaroff, AA, Wright, LL, Lemons, JA, Shankaran, S, Tyson, JE, Korones, SB, Bauer, CR, Stoll, BJ, Papile, LA, Donovan, EF, Ehrenkranz, RA, Stevenson, DK, Poland, RL, Hack, M, Newman, N, Tsang, RC, Mersmann, M, Brumley, GW, Goulding, CH, Verier, J, Levy, A, Mele, L, Denne, S, Appel, D, Bandstra, ES, Worth, A, Yaffe, SJ, Catz, C, Wright, L, Backstrom, C, Stevenson, DK, Ball, B, Bada, H, Hudson, T, Kennedy, K, Warner, S, Ostrea, E, Muran, G, Stonestreet, B, Hensman, A, Peterec, S & Gettner, P 1996, 'Interlaboratory variability of bilirubin measurements', Clinical Chemistry, vol. 42, no. 6 SUPPL., pp. 869-873.
Vreman HJ, Verter J, Oh W, Fanaroff AA, Wright LL, Lemons JA et al. Interlaboratory variability of bilirubin measurements. Clinical Chemistry. 1996;42(6 SUPPL.):869-873.
Vreman, Hendrik J. ; Verter, Joel ; Oh, William ; Fanaroff, Avroy A. ; Wright, Linda L. ; Lemons, James A. ; Shankaran, Seetha ; Tyson, Jon E. ; Korones, Sheldon B. ; Bauer, Charles R. ; Stoll, Barbara J. ; Papile, Lu Ann ; Donovan, Edward F. ; Ehrenkranz, Richard A. ; Stevenson, David K. ; Poland, Ronald L. ; Hack, Maureen ; Newman, Nancy ; Tsang, Reginald C. ; Mersmann, Marci ; Brumley, George W. ; Goulding, Cathy H. ; Verier, Joel ; Levy, Amalia ; Mele, Lisa ; Denne, Scott ; Appel, Diana ; Bandstra, Emmalee S. ; Worth, Amy ; Yaffe, Sumner J. ; Catz, Charlotte ; Wright, Linda ; Backstrom, Conra ; Stevenson, David K. ; Ball, Bethany ; Bada, Henrietta ; Hudson, Tina ; Kennedy, Kathleen ; Warner, Sherry ; Ostrea, Enrique ; Muran, Gerry ; Stonestreet, Barbara ; Hensman, Angelita ; Peterec, Steven ; Gettner, Patricia. / Interlaboratory variability of bilirubin measurements. In: Clinical Chemistry. 1996 ; Vol. 42, No. 6 SUPPL. pp. 869-873.
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abstract = "During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4{\%} at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.",
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T1 - Interlaboratory variability of bilirubin measurements

AU - Vreman, Hendrik J.

AU - Verter, Joel

AU - Oh, William

AU - Fanaroff, Avroy A.

AU - Wright, Linda L.

AU - Lemons, James A.

AU - Shankaran, Seetha

AU - Tyson, Jon E.

AU - Korones, Sheldon B.

AU - Bauer, Charles R.

AU - Stoll, Barbara J.

AU - Papile, Lu Ann

AU - Donovan, Edward F.

AU - Ehrenkranz, Richard A.

AU - Stevenson, David K.

AU - Poland, Ronald L.

AU - Hack, Maureen

AU - Newman, Nancy

AU - Tsang, Reginald C.

AU - Mersmann, Marci

AU - Brumley, George W.

AU - Goulding, Cathy H.

AU - Verier, Joel

AU - Levy, Amalia

AU - Mele, Lisa

AU - Denne, Scott

AU - Appel, Diana

AU - Bandstra, Emmalee S.

AU - Worth, Amy

AU - Yaffe, Sumner J.

AU - Catz, Charlotte

AU - Wright, Linda

AU - Backstrom, Conra

AU - Stevenson, David K.

AU - Ball, Bethany

AU - Bada, Henrietta

AU - Hudson, Tina

AU - Kennedy, Kathleen

AU - Warner, Sherry

AU - Ostrea, Enrique

AU - Muran, Gerry

AU - Stonestreet, Barbara

AU - Hensman, Angelita

AU - Peterec, Steven

AU - Gettner, Patricia

PY - 1996

Y1 - 1996

N2 - During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

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KW - Automated analysis

KW - Control material

KW - Quality control

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