Interleukin-6 activity in dogs with juvenile polyarteritis syndrome: effect of corticosteroids

Harm Hogenesch, Paul W. Snyder, J. Catharine R. Scott-Moncrieff, Larry T. Glickman, Peter J. Felsburg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Juvenile polyarteritis syndrome (JPS) is an idiopathic febrile disease in dogs. Elevated serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) have been reported in human patients with vasculitis. We investigated whether these cytokines are also elevated in serum of dogs with JPS using sensitive bio-assays. Increased levels of IL-6 activity were detected in the serum of 12 acutely ill dogs, whereas the IL-6 activity decreased to low or undetectable levels during convalescence. Treatment of 5 acute JPS dogs with prednisone resulted in a rapid clinical improvement accompanied by a decrease of IL-6 activity. Withdrawal of prednisone treatment caused reappearance of clinical symptoms and high serum IL-6 activity within a few days. TNF activity could not be detected in the samples of normal dogs, convalescent JPS, or acute JPS dogs. These studies support a role for IL-6 in the pathogenesis of JPS.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalClinical Immunology and Immunopathology
Volume77
Issue number1
DOIs
StatePublished - Oct 1995

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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