Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells

Jianhua S. Yao, Wenwu Zhai, Yongfeng Fan, Michael T. Lawton, Nicholas Barbaro, William L. Young, Guo Yuan Yang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Interleukin-6 (IL-6) may play multiple roles in angiogenesis and vascular remodeling. Our previous study showed that a promoter polymorphism (174G>C) in IL-6 is associated with brain arteriovenous malformation hemorrhage; tissue expression is related to genotype. In this study, we investigated the effects of IL-6 on human cerebral smooth muscle cells (HCSMCs) and smooth muscle cells isolated from brain arteriovenous malformation surgical specimens (AVM SMCs) and surgical controls (control HCSMCs - from structurally normal temporal lobe taken during surgical treatment of epilepsy patients). We found that IL-6 (1.1±0.27 versus 0.37±0.04 pg/mL, n=5, P

Original languageEnglish (US)
Pages (from-to)510-520
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number3
DOIs
StatePublished - Mar 14 2007
Externally publishedYes

Fingerprint

Smooth Muscle Myocytes
Interleukin-6
Up-Regulation
Arteriovenous Malformations
Brain
Temporal Lobe
Epilepsy
Genotype
Hemorrhage
Therapeutics

Keywords

  • Angiogenesis
  • Human cerebral smooth muscle cell
  • Interleukin-6
  • Matrix metalloproteinase
  • Proliferation
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. / Yao, Jianhua S.; Zhai, Wenwu; Fan, Yongfeng; Lawton, Michael T.; Barbaro, Nicholas; Young, William L.; Yang, Guo Yuan.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 27, No. 3, 14.03.2007, p. 510-520.

Research output: Contribution to journalArticle

Yao, Jianhua S. ; Zhai, Wenwu ; Fan, Yongfeng ; Lawton, Michael T. ; Barbaro, Nicholas ; Young, William L. ; Yang, Guo Yuan. / Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. In: Journal of Cerebral Blood Flow and Metabolism. 2007 ; Vol. 27, No. 3. pp. 510-520.
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