Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

Weiguo Yao, Yanlu Zhang, Rukhsana Jabeen, Evelyn T. Nguyen, David S. Wilkes, Robert S. Tepper, Mark H. Kaplan, Baohua Zhou

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine important for the initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this study, we identified a positive association between interleukin-9 (IL-9) and TSLP concentration in the serum of infants with atopic dermatitis. In primary cell cultures, the addition of TSLP led to an increase in IL-9 production from human and mouse Th9 cells, and induced an increase in signal transducer and activator of transcription 5 (STAT5) activation and binding to the . Il9 promoter. In vivo, use of an adoptive transfer model demonstrated that TSLP promoted IL-9-dependent, Th9 cell-induced allergic inflammation by acting directly on T cells. Moreover, transgenic expression of TSLP in the lung stimulated IL-9 production in vivo, and anti-IL-9 treatment attenuated TSLP-induced airway inflammation. Together, our results demonstrate that TSLP promotes Th9 cell differentiation and function and define a requirement for IL-9 in TSLP-induced allergic inflammation.

Original languageEnglish (US)
Pages (from-to)360-372
Number of pages13
JournalImmunity
Volume38
Issue number2
DOIs
StatePublished - Feb 21 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP'. Together they form a unique fingerprint.

  • Cite this