Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia

Alana M. Hahn, Jason D. Myers, Eliza K. McFarland, Sanghee Lee, Travis Jerde

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Prostatic inflammation is of considerable importance to urologic research because of its association with benign prostatic hyperplasia and prostate cancer. However, the mechanisms by which inflammation leads to proliferation and growth remain obscure. Here, we show that insulin-like growth factors (IGFs), previously known as critical developmental growth factors during prostate organogenesis, are induced by inflammation as part of the proliferative recovery to inflammation. Using genetic models and in vivo IGF receptor blockade, we demonstrate that the hyperplastic response to inflammation depends on interleukin-1-driven IGF signaling. We show that human prostatic hyperplasia is associated with IGF pathway activation specifically localized to foci of inflammation. This demonstrates that mechanisms of inflammation-induced epithelial proliferation and hyperplasia involve the induction of developmental growth factors, further establishing a link between inflammatory and developmental signals and providing a mechanistic basis for the management of proliferative diseases by IGF pathway modulation.

Original languageEnglish
Pages (from-to)606-615
Number of pages10
JournalJournal of Pharmacology and Experimental Therapeutics
Volume351
Issue number3
DOIs
StatePublished - Dec 1 2014

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Interleukins
Prostatic Hyperplasia
Somatomedins
Inflammation
Prostatic Neoplasms
Intercellular Signaling Peptides and Proteins
Somatomedin Receptors
Organogenesis
Genetic Models
Disease Management
Interleukin-1
Hyperplasia
Prostate
Growth
Research

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia. / Hahn, Alana M.; Myers, Jason D.; McFarland, Eliza K.; Lee, Sanghee; Jerde, Travis.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 351, No. 3, 01.12.2014, p. 606-615.

Research output: Contribution to journalArticle

Hahn, Alana M. ; Myers, Jason D. ; McFarland, Eliza K. ; Lee, Sanghee ; Jerde, Travis. / Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia. In: Journal of Pharmacology and Experimental Therapeutics. 2014 ; Vol. 351, No. 3. pp. 606-615.
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