Intermittent failure of local conduction during ventricular tachycardia

John Miller, J. A. Vassallo, W. C. Hargrove, M. E. Josephson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Forty-three patients with sustained ventricular tachycardia (VT) caused by prior myocardial infarction underwent intraoperative endocardial activation mapping during a total of 122 episodes of VT. Electrograms obtained during mapping were analyzed to determine the prevalence of local conduction failure during VT (defined as a portion of the local electrogram that did not repeat with every tachycardia cycle). Local conduction failure during VT was observed in 37 (86%) patients and 73 (65%) tachycardias. VT in which local conduction failure was observed were faster than VTs without local conduction failure (cycle length 315 vs 345 msec; p <.05). Local conduction failure occurred most frequently at or near sites having the earliest recorded electrical activity during VT ('site of origin'). Twenty-three patients also had sinus rhythm endocardial mapping at the time of surgery. Areas with abnormal or fractionated electrograms in sinus rhythm (16% vs 8%; p <.01). Although the mechanism responsible for local conduction failure in VT is unclear, it is a common occurrence and is significant in that it can occasionally mimic 'early' sites of endocardial activation, unless enough VT cycles are observed at a given site.

Original languageEnglish (US)
Pages (from-to)1286-1292
Number of pages7
JournalCirculation
Volume72
Issue number6
StatePublished - 1985
Externally publishedYes

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Ventricular Tachycardia
Tachycardia
Myocardial Infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Miller, J., Vassallo, J. A., Hargrove, W. C., & Josephson, M. E. (1985). Intermittent failure of local conduction during ventricular tachycardia. Circulation, 72(6), 1286-1292.

Intermittent failure of local conduction during ventricular tachycardia. / Miller, John; Vassallo, J. A.; Hargrove, W. C.; Josephson, M. E.

In: Circulation, Vol. 72, No. 6, 1985, p. 1286-1292.

Research output: Contribution to journalArticle

Miller, J, Vassallo, JA, Hargrove, WC & Josephson, ME 1985, 'Intermittent failure of local conduction during ventricular tachycardia', Circulation, vol. 72, no. 6, pp. 1286-1292.
Miller J, Vassallo JA, Hargrove WC, Josephson ME. Intermittent failure of local conduction during ventricular tachycardia. Circulation. 1985;72(6):1286-1292.
Miller, John ; Vassallo, J. A. ; Hargrove, W. C. ; Josephson, M. E. / Intermittent failure of local conduction during ventricular tachycardia. In: Circulation. 1985 ; Vol. 72, No. 6. pp. 1286-1292.
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