International transporter consortium commentary on clinically important transporter polymorphisms

K. M. Giacomini, P. V. Balimane, S. K. Cho, M. Eadon, T. Edeki, K. M. Hillgren, S. M. Huang, Y. Sugiyama, D. Weitz, Y. Wen, C. Q. Xia, S. W. Yee, H. Zimdahl, M. Niemi

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

This Commentary focuses on genetic polymorphisms in membrane transporters. We present two polymorphisms for which there is a compelling body of literature supporting their clinical relevance: OATP1B1 (c.521T>C, p.V174A, rs4149056) and BCRP (c.421C>A, p.Q141K, rs2231142). The clinical evidence demonstrating their role in variation in pharmacokinetics and pharmacodynamics is described along with their allele frequencies in ethnic populations. Recommendations for incorporating studies of transporter polymorphisms in drug development are provided, along with the regulatory implications.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume94
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

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Membrane Transport Proteins
Genetic Polymorphisms
Gene Frequency
Pharmacokinetics
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

International transporter consortium commentary on clinically important transporter polymorphisms. / Giacomini, K. M.; Balimane, P. V.; Cho, S. K.; Eadon, M.; Edeki, T.; Hillgren, K. M.; Huang, S. M.; Sugiyama, Y.; Weitz, D.; Wen, Y.; Xia, C. Q.; Yee, S. W.; Zimdahl, H.; Niemi, M.

In: Clinical Pharmacology and Therapeutics, Vol. 94, No. 1, 01.07.2013, p. 23-26.

Research output: Contribution to journalReview article

Giacomini, KM, Balimane, PV, Cho, SK, Eadon, M, Edeki, T, Hillgren, KM, Huang, SM, Sugiyama, Y, Weitz, D, Wen, Y, Xia, CQ, Yee, SW, Zimdahl, H & Niemi, M 2013, 'International transporter consortium commentary on clinically important transporter polymorphisms', Clinical Pharmacology and Therapeutics, vol. 94, no. 1, pp. 23-26. https://doi.org/10.1038/clpt.2013.12
Giacomini, K. M. ; Balimane, P. V. ; Cho, S. K. ; Eadon, M. ; Edeki, T. ; Hillgren, K. M. ; Huang, S. M. ; Sugiyama, Y. ; Weitz, D. ; Wen, Y. ; Xia, C. Q. ; Yee, S. W. ; Zimdahl, H. ; Niemi, M. / International transporter consortium commentary on clinically important transporter polymorphisms. In: Clinical Pharmacology and Therapeutics. 2013 ; Vol. 94, No. 1. pp. 23-26.
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AU - Hillgren, K. M.

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