Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity

Hua Wang, Ogyi Park, Fouad Lafdil, Kezhen Shen, Norio Horiguchi, Shi Yin, Xin Yuan Fu, George Kunos, Bin Gao

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Liver regeneration triggered by two-thirds partial hepatectomy is accompanied by elevated hepatic levels of endotoxin, which contributes to the regenerative process, but liver inflammation and apoptosis remain paradoxically limited. Here, we show that signal transducer and activator of transcription 3 (STAT3), an important anti-inflammatory signal, is activated in myeloid cells after partial hepatectomy and its conditional deletion results in an enhanced inflammatory response. Surprisingly, this is accompanied by an improved rather than impaired regenerative response with increased hepatic STAT3 activation, which may contribute to the enhanced liver regeneration. Indeed, conditional deletion of STAT3 in both hepatocytes and myeloid cells results in elevated activation of STAT1 and apoptosis of hepatocytes, and a dramatic reduction in survival after partial hepatectomy, whereas additional global deletion of STAT1 protects against these effects. Conclusion: An interplay of myeloid and hepatic STAT3 signaling is essential to prevent liver failure during liver regeneration through tempering a strong innate inflammatory response mediated by STAT1 signaling.

Original languageEnglish
Pages (from-to)1354-1362
Number of pages9
JournalHepatology
Volume51
Issue number4
DOIs
StatePublished - Apr 2010

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STAT3 Transcription Factor
Liver Regeneration
Innate Immunity
Hepatectomy
Liver
Myeloid Cells
Hepatocytes
Apoptosis
Liver Failure
Endotoxins
Transcriptional Activation
Anti-Inflammatory Agents
Inflammation

ASJC Scopus subject areas

  • Hepatology

Cite this

Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. / Wang, Hua; Park, Ogyi; Lafdil, Fouad; Shen, Kezhen; Horiguchi, Norio; Yin, Shi; Fu, Xin Yuan; Kunos, George; Gao, Bin.

In: Hepatology, Vol. 51, No. 4, 04.2010, p. 1354-1362.

Research output: Contribution to journalArticle

Wang, H, Park, O, Lafdil, F, Shen, K, Horiguchi, N, Yin, S, Fu, XY, Kunos, G & Gao, B 2010, 'Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity', Hepatology, vol. 51, no. 4, pp. 1354-1362. https://doi.org/10.1002/hep.23430
Wang, Hua ; Park, Ogyi ; Lafdil, Fouad ; Shen, Kezhen ; Horiguchi, Norio ; Yin, Shi ; Fu, Xin Yuan ; Kunos, George ; Gao, Bin. / Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. In: Hepatology. 2010 ; Vol. 51, No. 4. pp. 1354-1362.
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AU - Yin, Shi

AU - Fu, Xin Yuan

AU - Kunos, George

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