Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease

B. Early, P. R. Escalona, Orest Boyko, P. M. Doraiswamy, D. A. Axelson, L. Patterson, W. M. McDonald, K. R R Krishnan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the volume of the amygdala hippocampal complex obtained from coronal MR images. The IUD was also measured on axial MR scans in 12 patients with possible or probable Alzheimer disease. RESULTS: The correlation between the total amygdala hippocampal volume and the IUD was insignificant for control subjects (r = -0.38, P = .13). When analysis of covariance was performed with the IUD as the dependent variable and age and diagnosis as the independent variables, overall R2 was 0.25. Age (F = 5.02, df = 1, P = .034), but not diagnosis (F = 0.02, df = 2, P = .88), had a significant effect. CONCLUSIONS: The IUD has no significant correlation with the amygdala hippocampal volume. The IUD appears to be a better measure of overall brain volume, which changes with age. In our patient population diagnosed with mild to moderate Alzheimer disease, the IUD measurement was not found to be useful in distinguishing their scans from those of the volunteers.

Original languageEnglish (US)
Pages (from-to)907-910
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume14
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Amygdala
Healthy Volunteers
Alzheimer Disease
Atrophy
Volunteers
Brain
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Early, B., Escalona, P. R., Boyko, O., Doraiswamy, P. M., Axelson, D. A., Patterson, L., ... Krishnan, K. R. R. (1993). Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease. American Journal of Neuroradiology, 14(4), 907-910.

Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease. / Early, B.; Escalona, P. R.; Boyko, Orest; Doraiswamy, P. M.; Axelson, D. A.; Patterson, L.; McDonald, W. M.; Krishnan, K. R R.

In: American Journal of Neuroradiology, Vol. 14, No. 4, 1993, p. 907-910.

Research output: Contribution to journalArticle

Early, B, Escalona, PR, Boyko, O, Doraiswamy, PM, Axelson, DA, Patterson, L, McDonald, WM & Krishnan, KRR 1993, 'Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease', American Journal of Neuroradiology, vol. 14, no. 4, pp. 907-910.
Early B, Escalona PR, Boyko O, Doraiswamy PM, Axelson DA, Patterson L et al. Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease. American Journal of Neuroradiology. 1993;14(4):907-910.
Early, B. ; Escalona, P. R. ; Boyko, Orest ; Doraiswamy, P. M. ; Axelson, D. A. ; Patterson, L. ; McDonald, W. M. ; Krishnan, K. R R. / Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease. In: American Journal of Neuroradiology. 1993 ; Vol. 14, No. 4. pp. 907-910.
@article{e18885553ca8489aa44d60c2f75721f3,
title = "Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease",
abstract = "PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the volume of the amygdala hippocampal complex obtained from coronal MR images. The IUD was also measured on axial MR scans in 12 patients with possible or probable Alzheimer disease. RESULTS: The correlation between the total amygdala hippocampal volume and the IUD was insignificant for control subjects (r = -0.38, P = .13). When analysis of covariance was performed with the IUD as the dependent variable and age and diagnosis as the independent variables, overall R2 was 0.25. Age (F = 5.02, df = 1, P = .034), but not diagnosis (F = 0.02, df = 2, P = .88), had a significant effect. CONCLUSIONS: The IUD has no significant correlation with the amygdala hippocampal volume. The IUD appears to be a better measure of overall brain volume, which changes with age. In our patient population diagnosed with mild to moderate Alzheimer disease, the IUD measurement was not found to be useful in distinguishing their scans from those of the volunteers.",
author = "B. Early and Escalona, {P. R.} and Orest Boyko and Doraiswamy, {P. M.} and Axelson, {D. A.} and L. Patterson and McDonald, {W. M.} and Krishnan, {K. R R}",
year = "1993",
language = "English (US)",
volume = "14",
pages = "907--910",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "4",

}

TY - JOUR

T1 - Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease

AU - Early, B.

AU - Escalona, P. R.

AU - Boyko, Orest

AU - Doraiswamy, P. M.

AU - Axelson, D. A.

AU - Patterson, L.

AU - McDonald, W. M.

AU - Krishnan, K. R R

PY - 1993

Y1 - 1993

N2 - PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the volume of the amygdala hippocampal complex obtained from coronal MR images. The IUD was also measured on axial MR scans in 12 patients with possible or probable Alzheimer disease. RESULTS: The correlation between the total amygdala hippocampal volume and the IUD was insignificant for control subjects (r = -0.38, P = .13). When analysis of covariance was performed with the IUD as the dependent variable and age and diagnosis as the independent variables, overall R2 was 0.25. Age (F = 5.02, df = 1, P = .034), but not diagnosis (F = 0.02, df = 2, P = .88), had a significant effect. CONCLUSIONS: The IUD has no significant correlation with the amygdala hippocampal volume. The IUD appears to be a better measure of overall brain volume, which changes with age. In our patient population diagnosed with mild to moderate Alzheimer disease, the IUD measurement was not found to be useful in distinguishing their scans from those of the volunteers.

AB - PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the volume of the amygdala hippocampal complex obtained from coronal MR images. The IUD was also measured on axial MR scans in 12 patients with possible or probable Alzheimer disease. RESULTS: The correlation between the total amygdala hippocampal volume and the IUD was insignificant for control subjects (r = -0.38, P = .13). When analysis of covariance was performed with the IUD as the dependent variable and age and diagnosis as the independent variables, overall R2 was 0.25. Age (F = 5.02, df = 1, P = .034), but not diagnosis (F = 0.02, df = 2, P = .88), had a significant effect. CONCLUSIONS: The IUD has no significant correlation with the amygdala hippocampal volume. The IUD appears to be a better measure of overall brain volume, which changes with age. In our patient population diagnosed with mild to moderate Alzheimer disease, the IUD measurement was not found to be useful in distinguishing their scans from those of the volunteers.

UR - http://www.scopus.com/inward/record.url?scp=0027302512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027302512&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 907

EP - 910

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 4

ER -