Intervention in necrotizing pancreatitis: An evidence-based review of surgical and percutaneous alternatives

Edward L. Bradley, Thomas Howard, Eric Van Sonnenberg, Mehran Fotoohi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.

Original languageEnglish
Pages (from-to)634-639
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Pancreatitis
Necrosis
Intra Arterial Infusions
Protease Inhibitors
Anti-Bacterial Agents
Therapeutics

Keywords

  • Continuous regional intraarterial protease infusion
  • Guided percutaneous drainage
  • Infected necrosis
  • Laparoscopy
  • Minimally invasive
  • Pancreatic necrosis
  • Surgical debridement

ASJC Scopus subject areas

  • Surgery

Cite this

Intervention in necrotizing pancreatitis : An evidence-based review of surgical and percutaneous alternatives. / Bradley, Edward L.; Howard, Thomas; Van Sonnenberg, Eric; Fotoohi, Mehran.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 4, 04.2008, p. 634-639.

Research output: Contribution to journalArticle

@article{551426fd2e5c417e9aac04f7a253c952,
title = "Intervention in necrotizing pancreatitis: An evidence-based review of surgical and percutaneous alternatives",
abstract = "Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.",
keywords = "Continuous regional intraarterial protease infusion, Guided percutaneous drainage, Infected necrosis, Laparoscopy, Minimally invasive, Pancreatic necrosis, Surgical debridement",
author = "Bradley, {Edward L.} and Thomas Howard and {Van Sonnenberg}, Eric and Mehran Fotoohi",
year = "2008",
month = "4",
doi = "10.1007/s11605-007-0445-z",
language = "English",
volume = "12",
pages = "634--639",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Intervention in necrotizing pancreatitis

T2 - An evidence-based review of surgical and percutaneous alternatives

AU - Bradley, Edward L.

AU - Howard, Thomas

AU - Van Sonnenberg, Eric

AU - Fotoohi, Mehran

PY - 2008/4

Y1 - 2008/4

N2 - Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.

AB - Interventional therapy in necrotizing pancreatitis is evolving. Efforts to modify or prevent pancreatic necrosis by intra-arterial infusion of antibiotics and antiproteases have been described. Moreover, traditional approaches to the surgical management of infected pancreatic necrosis are being challenged by a host of endoscopic and percutaneous techniques. While these approaches are potentially valuable additions to interventional therapy in necrotizing pancreatitis, few evidence-based studies are available to support their supplanting more traditional approaches at this time. Cooperative evidence-based multiinstitutional studies will be required to address the validity of these proposals.

KW - Continuous regional intraarterial protease infusion

KW - Guided percutaneous drainage

KW - Infected necrosis

KW - Laparoscopy

KW - Minimally invasive

KW - Pancreatic necrosis

KW - Surgical debridement

UR - http://www.scopus.com/inward/record.url?scp=40849142501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40849142501&partnerID=8YFLogxK

U2 - 10.1007/s11605-007-0445-z

DO - 10.1007/s11605-007-0445-z

M3 - Article

C2 - 18172609

AN - SCOPUS:40849142501

VL - 12

SP - 634

EP - 639

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 4

ER -