Interventional and device-based autonomic modulation in heart failure

Mark J. Shen, Douglas P. Zipes

Research output: Contribution to journalReview article

12 Scopus citations


"Heart failure is an increasingly prevalent disease with high mortality and public health burden. It is associated with autonomic imbalance characterized by sympathetic hyperactivity and parasympathetic hypoactivity. Evolving novel interventional and device-based therapies have sought to restore autonomic balance by neuromodulation. Results of preclinical animal studies and early clinical trials have demonstrated the safety and efficacy of these therapies in heart failure. This article discusses specific neuromodulatory treatment modalities individually-spinal cord stimulation, vagus nerve stimulation, baroreceptor activation therapy, and renal sympathetic nerve denervation".

Original languageEnglish (US)
Pages (from-to)337-348
Number of pages12
JournalHeart Failure Clinics
Issue number2
StatePublished - Apr 1 2015


  • Autonomic nervous system
  • Baroreflex activation therapy
  • Heart failure
  • Renal sympathetic nerve denervation
  • Spinal cord stimulation
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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