Interventions for developmental delays in children born to HIV-infected mothers: a systematic review

Megan McHenry, Carole Ian McAteer, Eren Oyungu, Andrew Roland Deathe, Rachel Vreeman

Research output: Contribution to journalArticle

Abstract

Children born to HIV-infected mothers have worse developmental outcomes compared to HIV-unexposed children. However, little is known about interventions to improve developmental outcomes in this population. This study systematically reviews the literature on interventions to improve development in children born to HIV-infected mothers. We systematically searched the following electronic bibliographic databases: Ovid MEDLINE, Embase, PsycINFO, Education Resources Information Center, and the Cochrane Database of Systematic Reviews. Studies were selected on the basis of defined inclusion criteria and excluded if antiretroviral medication was the only intervention. Titles, abstracts, and full texts were assessed by 2 independent reviewers. Data were collected on characteristics of the study design, intervention, and developmental outcomes measured. Risk of bias and strength of evidence were assessed on all included articles. Our search resulted in 11,218 records. After our initial review, 43 records were appraised in their entirety and 9 studies met all inclusion criteria. Six were performed in sub-Saharan Africa, while the remaining 3 were performed in the United States. Eight were randomized-controlled trials and one was a retrospective chart review. Four studies focused on caregiver-training, 2 studied massage therapy, and the remaining studies focused on maternal vitamin supplementation, video-based cognitive therapy, or center-based interventions. Massage therapy had the most consistent improvements in the domains measured, while caregiver training and cognitive therapy interventions had limited benefits. The center-based intervention showed no benefit. Only 3 studies had a low risk of bias, and 4 studies had good strength of evidence. Most studies found some benefit. However, these findings are limited by the quality of the study designs, small sample size, and heterogeneity of the interventions and assessments used to measure outcomes. There is a critical need for the creation of evidence-based interventions to promote development in this vulnerable population.

Original languageEnglish (US)
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Massage
Mothers
HIV
Cognitive Therapy
Caregivers
Bibliographic Databases
Information Centers
Africa South of the Sahara
Vulnerable Populations
Child Development
Vitamins
MEDLINE
Sample Size
Randomized Controlled Trials
Outcome Assessment (Health Care)
Databases
Education
caregiver
inclusion
Population

Keywords

  • child development
  • developmental delays
  • HIV
  • intervention
  • pediatrics

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

Cite this

Interventions for developmental delays in children born to HIV-infected mothers : a systematic review. / McHenry, Megan; McAteer, Carole Ian; Oyungu, Eren; Deathe, Andrew Roland; Vreeman, Rachel.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 01.01.2018.

Research output: Contribution to journalArticle

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