Interventions to improve the physical function of ICU survivors: A systematic review

Enrique Calvo-Ayala, Babar Khan, Mark O. Farber, E. Wesley Ely, Malaz Boustani

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: ICU admissions are ever increasing across the United States. Following critical illness, physical functioning (PF) may be impaired for up to 5 years. We performed a systematic review of randomized controlled trials evaluating the efficacy of interventions targeting PF among ICU survivors. The objective of this study was to identify effective interventions that improve longterm PF in ICU survivors. Methods: MEDLINE, Excerpta Medica Database (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Physiotherapy Evidence-Based Database (PEDro) were searched between 1990 and 2012. Two reviewers independently evaluated studies for eligibility, critically appraised the included studies, and extracted data into standardized evidence tables. Results: Fourteen studies met the inclusion criteria. Interventions included exercise/physical therapy (PT), parenteral nutrition, nurse-led follow-up, spontaneous awakening trials, absence of sedation during mechanical ventilation, and early tracheotomy. Nine studies failed to demonstrate efficacy on PF of the ICU survivors. However, early physical exercise and PT-based interventions had a positive effect on long-term PF. Conclusions: The only effective intervention to improve long-term PF in critically ill patients is exercise/PT; its benefit may be greater if started earlier. Further research in this area comparing different interventions and timing is needed.

Original languageEnglish
Pages (from-to)1469-1480
Number of pages12
JournalChest
Volume144
Issue number5
DOIs
StatePublished - Nov 2013

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Exercise Therapy
Survivors
Critical Illness
Databases
Tracheotomy
Parenteral Nutrition
Artificial Respiration
MEDLINE
Nursing
Randomized Controlled Trials
Nurses
Exercise
Health
Research

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Interventions to improve the physical function of ICU survivors : A systematic review. / Calvo-Ayala, Enrique; Khan, Babar; Farber, Mark O.; Wesley Ely, E.; Boustani, Malaz.

In: Chest, Vol. 144, No. 5, 11.2013, p. 1469-1480.

Research output: Contribution to journalArticle

Calvo-Ayala, Enrique ; Khan, Babar ; Farber, Mark O. ; Wesley Ely, E. ; Boustani, Malaz. / Interventions to improve the physical function of ICU survivors : A systematic review. In: Chest. 2013 ; Vol. 144, No. 5. pp. 1469-1480.
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