Abstract
This study evaluated the possibility that the endothelial cells of microscopic lymphatic vessels can release vasoactive agents which affect the lymphatic vessels and nearby arterioles. Microiontophoresis of acetylcholine (ACh) or bradykinin (BK) onto the wall of quiescent submucosal lymphatic vessels in the rat small intestine had no discernible effects on their diameters but caused spontaneously active mesenteric lymphatic vessels to constrict. Application of ACh or BK to the arteriolar wall caused significant vasodilation. Release of either drug onto the wall of a nearby lymphatic produced arteriolar dilation that was ~80% of that observed with direct application to the arteriolar wall; drug application into parenchymal tissue produced a dilation <25% of that observed during application to the lymphatic. N(G)-monomethyl-L-arginine application to the lymphatic blocked all ACh-induced lymphatic-mediated responses but had no effect on the response to direct ACh application to the arteriolar wall or any of the responses to BK application. These results are consistent with the hypothesis that lymphatic endothelial cells are capable of releasing agents that dilate nearby arterioles and cause spontaneously active lymphatic vessels to constrict.
| Original language | English (US) |
|---|---|
| Pages (from-to) | H813-H818 |
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 262 |
| Issue number | 3 31-3 |
| State | Published - Jan 1 1992 |
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Keywords
- acetylcholine
- arterioles
- bradykinin
- endothelial cells
ASJC Scopus subject areas
- Physiology
Cite this
Intestinal lymphatic vessels release endothelial-dependent vasodilators. / Bohlen, H. G.; Lash, J. M.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 3 31-3, 01.01.1992, p. H813-H818.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intestinal lymphatic vessels release endothelial-dependent vasodilators
AU - Bohlen, H. G.
AU - Lash, J. M.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - This study evaluated the possibility that the endothelial cells of microscopic lymphatic vessels can release vasoactive agents which affect the lymphatic vessels and nearby arterioles. Microiontophoresis of acetylcholine (ACh) or bradykinin (BK) onto the wall of quiescent submucosal lymphatic vessels in the rat small intestine had no discernible effects on their diameters but caused spontaneously active mesenteric lymphatic vessels to constrict. Application of ACh or BK to the arteriolar wall caused significant vasodilation. Release of either drug onto the wall of a nearby lymphatic produced arteriolar dilation that was ~80% of that observed with direct application to the arteriolar wall; drug application into parenchymal tissue produced a dilation <25% of that observed during application to the lymphatic. N(G)-monomethyl-L-arginine application to the lymphatic blocked all ACh-induced lymphatic-mediated responses but had no effect on the response to direct ACh application to the arteriolar wall or any of the responses to BK application. These results are consistent with the hypothesis that lymphatic endothelial cells are capable of releasing agents that dilate nearby arterioles and cause spontaneously active lymphatic vessels to constrict.
AB - This study evaluated the possibility that the endothelial cells of microscopic lymphatic vessels can release vasoactive agents which affect the lymphatic vessels and nearby arterioles. Microiontophoresis of acetylcholine (ACh) or bradykinin (BK) onto the wall of quiescent submucosal lymphatic vessels in the rat small intestine had no discernible effects on their diameters but caused spontaneously active mesenteric lymphatic vessels to constrict. Application of ACh or BK to the arteriolar wall caused significant vasodilation. Release of either drug onto the wall of a nearby lymphatic produced arteriolar dilation that was ~80% of that observed with direct application to the arteriolar wall; drug application into parenchymal tissue produced a dilation <25% of that observed during application to the lymphatic. N(G)-monomethyl-L-arginine application to the lymphatic blocked all ACh-induced lymphatic-mediated responses but had no effect on the response to direct ACh application to the arteriolar wall or any of the responses to BK application. These results are consistent with the hypothesis that lymphatic endothelial cells are capable of releasing agents that dilate nearby arterioles and cause spontaneously active lymphatic vessels to constrict.
KW - acetylcholine
KW - arterioles
KW - bradykinin
KW - endothelial cells
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UR - http://www.scopus.com/inward/citedby.url?scp=0026608721&partnerID=8YFLogxK
M3 - Article
C2 - 1558191
AN - SCOPUS:0026608721
VL - 262
SP - H813-H818
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6135
IS - 3 31-3
ER -