Intestinal transplant registry report: Global activity and trends

D. Grant, K. Abu-Elmagd, G. Mazariegos, R. Vianna, A. Langnas, Richard Mangus, D. G. Farmer, F. Lacaille, K. Iyer, T. Fishbein

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

The Registry has gathered information on intestine transplantation (IT) since 1985. During this time, individual centers have reported progress but small case volumes potentially limit the generalizability of this information. The present study was undertaken to examine recent global IT activity. Activity was assessed with descriptive statistics, Kaplan-Meier survival curves and a multiple variable analysis. Eighty-two programs reported 2887 transplants in 2699 patients. Regional practices and outcomes are now similar worldwide. Current actuarial patient survival rates are 76%, 56% and 43% at 1, 5 and 10 years, respectively. Rates of graft loss beyond 1 year have not improved. Grafts that included a colon segment had better function. Waiting at home for IT, the use of induction immune-suppression therapy, inclusion of a liver component and maintenance therapy with rapamycin were associated with better graft survival. Outcomes of IT have modestly improved over the past decade. Case volumes have recently declined. Identifying the root reasons for late graft loss is difficult due to the low case volumes at most centers. The high participation rate in the Registry provides unique opportunities to study these issues. The authors analyze worldwide data from the Intestinal Transplant Registry to explore the recent decline in case volumes and describe the modest improvement in outcomes over the past decade.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalAmerican Journal of Transplantation
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Registries
Intestines
Transplants
Transplantation
Kaplan-Meier Estimate
Graft Survival
Sirolimus
Colon
Survival Rate
Liver
Therapeutics

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Grant, D., Abu-Elmagd, K., Mazariegos, G., Vianna, R., Langnas, A., Mangus, R., ... Fishbein, T. (2015). Intestinal transplant registry report: Global activity and trends. American Journal of Transplantation, 15(1), 210-219. https://doi.org/10.1111/ajt.12979

Intestinal transplant registry report : Global activity and trends. / Grant, D.; Abu-Elmagd, K.; Mazariegos, G.; Vianna, R.; Langnas, A.; Mangus, Richard; Farmer, D. G.; Lacaille, F.; Iyer, K.; Fishbein, T.

In: American Journal of Transplantation, Vol. 15, No. 1, 01.01.2015, p. 210-219.

Research output: Contribution to journalArticle

Grant, D, Abu-Elmagd, K, Mazariegos, G, Vianna, R, Langnas, A, Mangus, R, Farmer, DG, Lacaille, F, Iyer, K & Fishbein, T 2015, 'Intestinal transplant registry report: Global activity and trends', American Journal of Transplantation, vol. 15, no. 1, pp. 210-219. https://doi.org/10.1111/ajt.12979
Grant, D. ; Abu-Elmagd, K. ; Mazariegos, G. ; Vianna, R. ; Langnas, A. ; Mangus, Richard ; Farmer, D. G. ; Lacaille, F. ; Iyer, K. ; Fishbein, T. / Intestinal transplant registry report : Global activity and trends. In: American Journal of Transplantation. 2015 ; Vol. 15, No. 1. pp. 210-219.
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