Intra arterial infusion therapy with 5 (3,3 dimethyl 1 triazeno) imidazole 4 carboxamide (NSC 45388) for malignant melanoma

Lawrence Einhorn, C. M. McBride, J. K. Luce, E. Caoili, J. A. Gottlieb

Research output: Contribution to journalArticle

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Abstract

Seventeen patients with advanced regional malignant melanoma were treated with intra arterial 5 (3,3 dimethyl 1 triazeno) imidazole 4 carboxamide (DTIC) in an attempt to improve the response rate to this drug. There were 6 partial objective (greater than 50% reduction) responders and one complete remission for an overall response rate of 41%. The local control of melanoma by this modality of treatment was impressive, and toxicity was less than that which is usually seen with systemic chemotherapy with DTIC. The studies suggest intra arterial therapy is preferrable to systemic therapy for the isolated inoperable melanoma lesion.

Original languageEnglish (US)
Pages (from-to)749-755
Number of pages7
JournalCancer
Volume32
Issue number4
DOIs
StatePublished - 1973
Externally publishedYes

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Intra Arterial Infusions
Dacarbazine
Melanoma
Therapeutics
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Intra arterial infusion therapy with 5 (3,3 dimethyl 1 triazeno) imidazole 4 carboxamide (NSC 45388) for malignant melanoma. / Einhorn, Lawrence; McBride, C. M.; Luce, J. K.; Caoili, E.; Gottlieb, J. A.

In: Cancer, Vol. 32, No. 4, 1973, p. 749-755.

Research output: Contribution to journalArticle

Einhorn, Lawrence ; McBride, C. M. ; Luce, J. K. ; Caoili, E. ; Gottlieb, J. A. / Intra arterial infusion therapy with 5 (3,3 dimethyl 1 triazeno) imidazole 4 carboxamide (NSC 45388) for malignant melanoma. In: Cancer. 1973 ; Vol. 32, No. 4. pp. 749-755.
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