Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl

Meredith Golomb, Mubeen Rafay, Derek Armstrong, Patricia Massicotte, Rosalind Curtis, Selina Hune, Gabrielle A. deVeber

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Few reports describe the use of intra-arterial recombinant tissue plasminogen activator to treat intracranial thrombosis in children. A 17-year-old girl with a history of prior venous thrombosis developed a left middle cerebral artery thrombus during diagnostic cerebral angiogram. Therapy with intra-arterial tissue plasminogen activator was initiated. An immediate follow-up angiogram demonstrated recanalization, and diffusion-weighted magnetic resonance imaging 9 hours later showed no evidence of infarction. Following the angiogram, femoral artery thrombosis developed. Treatment with supratherapeutic levels of heparin, localized delivery of intra-arterial tissue plasminogen activator, embolectomy, danaparoid, and dipyridamole failed to re-establish perfusion to the lower leg, and below the knee amputation was required. Neurologic examination remained normal 1 year later. Cerebral damage was avoided with the use of emergency intra-arterial tissue plasminogen activator for cerebral artery thrombosis in this child.

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalJournal of Child Neurology
Volume18
Issue number6
StatePublished - Jun 1 2003

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Cerebral Angiography
Tissue Plasminogen Activator
Intracranial Thrombosis
Thrombosis
Angiography
Embolectomy
Diffusion Magnetic Resonance Imaging
Cerebral Arteries
Dipyridamole
Middle Cerebral Artery
Neurologic Examination
Femoral Artery
Amputation
Venous Thrombosis
Infarction
Heparin
Leg
Knee
Emergencies
Perfusion

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Golomb, M., Rafay, M., Armstrong, D., Massicotte, P., Curtis, R., Hune, S., & deVeber, G. A. (2003). Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl. Journal of Child Neurology, 18(6), 420-423.

Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl. / Golomb, Meredith; Rafay, Mubeen; Armstrong, Derek; Massicotte, Patricia; Curtis, Rosalind; Hune, Selina; deVeber, Gabrielle A.

In: Journal of Child Neurology, Vol. 18, No. 6, 01.06.2003, p. 420-423.

Research output: Contribution to journalArticle

Golomb, M, Rafay, M, Armstrong, D, Massicotte, P, Curtis, R, Hune, S & deVeber, GA 2003, 'Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl', Journal of Child Neurology, vol. 18, no. 6, pp. 420-423.
Golomb, Meredith ; Rafay, Mubeen ; Armstrong, Derek ; Massicotte, Patricia ; Curtis, Rosalind ; Hune, Selina ; deVeber, Gabrielle A. / Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl. In: Journal of Child Neurology. 2003 ; Vol. 18, No. 6. pp. 420-423.
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