Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden

PREDICT-HD Investigators of the Huntington Study Group

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV across 15 neuropsychological tasks and within-task IIV using a self-paced timing task were compared as a single measure of processing speed (Symbol Digit Modalities Test [SDMT]) in 693 gene-expanded and 191 nongene-expanded participants from the PREDICT-HD study. After adjusting for depressive symptoms and motor functioning, individuals estimated to be closest to HD diagnosis displayed higher levels of across- and within-task variability when compared to controls and those prodromal HD participants far from disease onset (FICV(3,877) = 11.25; p<.0001; FPacedTiming(3,877) = 22.89; p<.0001). When prodromal HD participants closest to HD diagnosis were compared to controls, Cohen's d effect sizes were larger in magnitude for the within-task variability measure, paced timing (-1.01), and the SDMT (-0.79) and paced tapping coefficient of variation (CV) (-0.79) compared to the measures of across-task variability [CV (0.55); intra-individual standard deviation (0.26)]. Across-task variability may be a sensitive marker of cognitive decline in individuals with prodromal HD approaching disease onset. However, individual neuropsychological tasks, including a measure of within-task variability, produced larger effect sizes than an index of across-task IIV in this sample. (JINS, 2015, 21, 8-21)

Original languageEnglish (US)
Pages (from-to)8-21
Number of pages14
JournalJournal of the International Neuropsychological Society
Volume21
Issue number1
DOIs
StatePublished - Nov 12 2015

Keywords

  • Adult
  • Attention
  • Cognition disorders/diagnosis
  • Cognition disorders/genetics
  • Executive function
  • Huntington disease
  • Intra-individual variability
  • Neuropsychological tests
  • Prodromal symptoms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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