Intraamniotic urea for induction of mid-trimester abortion

Paul C. Weinberg, Marguerite K. Shepard

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Because potential hazards are associated with mid-trimester abortions induced by imraamniotic hypertonic saline, this study of ltypertonic urea was undertaken. One hundred twenty patients were studied. The mean in-jection to abortion interval was 51.1 hours (median 15.5 hours) for those aborting during initial hospitalization (117 patients). Eighty percent of the group aborted within 72 hours. Complications of amniocentesis, such as infection, bleeding and retained products, were similar to those experienced with hypertonic saline. None of the hazardous complications of hypertonic saline was experienced in this study population. Urea avoids the potentially lethal complications of accidental intravascular injection of hiypertonic saline and is an effective abortifacient.

Original languageEnglish (US)
Pages (from-to)451-454
Number of pages4
JournalObstetrics and gynecology
Issue number3
StatePublished - Mar 1973
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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