Intracellular Calcium Dynamics and Autonomic Stimulation in Atrial Fibrillation: Mechanisms and Implications

Chung Chuan Chou, Delon Wu, Peng Sheng Chen

Research output: Contribution to journalArticle

Abstract

While atrial fibrillation is characterized by the co-existence of multiple activation waves within the atria, rapid activations in the pulmonary veins play an important role for the initiation and maintenance of atrial fibrillation. In addition to reentry, non-reentrant mechanisms resulting from abnormal intracellular calcium handling and intracellular calcium overload can also be responsible for these rapid activations in the pulmonary veins. Meanwhile, alterations of autonomic tone, involving both the sympathetic and parasympathetic nervous system, have been implicated in initiating paroxysmal atrial fibrillation. But the effectiveness of autonomic modulation as an adjunctive therapeutic strategy to catheter ablation of atrial fibrillation has been inconsistent. The interactions between the autonomic nervous system and atrial fibrillation are more complex than currently understood and further mechanistic and clinical studies are warranted.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
Journaljournal of arrhythmia
Volume24
Issue number2
DOIs
StatePublished - Jan 1 2008

Keywords

  • Atrium
  • Autonomic
  • Calcium
  • Fibrillation
  • Nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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