Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients

Ting Wang, Linden A. Green, Samir Gupta, Tohti Amet, Daniel J. Byrd, Andy Yu, Homer Twigg, Matthias Clauss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2015

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Blood Cells
HIV
Therapeutics
Pathology
Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients. / Wang, Ting; Green, Linden A.; Gupta, Samir; Amet, Tohti; Byrd, Daniel J.; Yu, Andy; Twigg, Homer; Clauss, Matthias.

In: AIDS Research and Human Retroviruses, Vol. 31, No. 2, 01.02.2015, p. 217-220.

Research output: Contribution to journalArticle

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