Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients

Ting Wang, Linden A. Green, Samir K. Gupta, Tohti Amet, Daniel J. Byrd, Qigui Yu, Homer L. Twigg, Matthias Clauss

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalAIDS Research and Human Retroviruses
Issue number2
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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