Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Hemamali Samaratunga, Brett Delahunt, Lars Egevad, John R. Srigley, Athanase Billis, David G. Bostwick, Philippe Camparo, Liang Cheng, David Clouston, James Denham, Bungo Furusato, Arndt Hartmann, Laura Jufe, James Kench, Diane N. Kenwright, Glen Kristiansen, Katia R.M. Leite, Gregory T. MacLennan, Jennifer Merrimen, Holger MochJon Oxley, Chin Chen Pan, Gladell Paner, Jae Ro, Isabell A.M. Sesterhenn, Jonathan Shanks, Michelle Thunders, Toyonori Tsuzuki, Thomas Wheeler, John W. Yaxley, Murali Varma

Research output: Contribution to journalReview article

Abstract

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalPathology
Volume52
Issue number2
DOIs
StatePublished - Feb 2020

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Keywords

  • ISUP grade
  • Prostate adenocarcinoma
  • intraductal carcinoma of prostate
  • prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Samaratunga, H., Delahunt, B., Egevad, L., Srigley, J. R., Billis, A., Bostwick, D. G., Camparo, P., Cheng, L., Clouston, D., Denham, J., Furusato, B., Hartmann, A., Jufe, L., Kench, J., Kenwright, D. N., Kristiansen, G., Leite, K. R. M., MacLennan, G. T., Merrimen, J., ... Varma, M. (2020). Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology, 52(2), 192-196. https://doi.org/10.1016/j.pathol.2019.11.001