Intraductal papillary mucinous neoplasm of the pancreas, one manifestation of a more systemic disease?

Alexandra M. Roch, Carlo Maria Rosati, Jessica L. Cioffi, Eugene P. Ceppa, John M. Dewitt, Mohammad A. Al-Haddad, Michael G. House, Nicholas J. Zyromski, Attila Nakeeb, C. Max Schmidt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background Several studies have demonstrated a high prevalence of extrapancreatic malignancies, and an association with autoimmune pancreatitis in patients with intraductal papillary mucinous neoplasm (IPMN). We hypothesized that IPMNs were associated with an increase rate of systemic diseases. Methods From 1996 to 2013, a retrospective analysis of a prospectively collected database was performed and supplemented with electronic medical charts review. Results Two hundred twenty extrapancreatic malignancies were found in 185 patients (22%) compared with expected 5% in the general population. Colorectal, lung, and renal cell carcinoma had significant observed/expected ratios (P <.0001). One hundred ten synchronous autoimmune diseases were found in 96 patients (11%). Systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease showed statistically significant observed/expected ratios (P <.0001,.01, and <.0001, respectively). There was no impact of immunosuppressive treatment on the IPMN subtype and malignancy rate. Conclusions IPMN are associated with surprisingly high rates of autoimmune diseases suggesting that IPMN might be 1 manifestation of a more systemic disease.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalAmerican Journal of Surgery
Volume211
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Autoimmune diseases
  • Extrapancreatic malignancies
  • Incidence
  • Intraductal papillary mucinous neoplasm

ASJC Scopus subject areas

  • Surgery

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