Intraductal papillary mucinous neoplasm of the pancreas, one manifestation of a more systemic disease?

Alexandra M. Roch, Carlo Maria Rosati, Jessica L. Cioffi, Eugene P. Ceppa, John DeWitt, Mohammad A. Al-Haddad, Michael House, Nicholas Zyromski, Attila Nakeeb, C. Schmidt

Research output: Contribution to journalArticle

4 Scopus citations


Background Several studies have demonstrated a high prevalence of extrapancreatic malignancies, and an association with autoimmune pancreatitis in patients with intraductal papillary mucinous neoplasm (IPMN). We hypothesized that IPMNs were associated with an increase rate of systemic diseases. Methods From 1996 to 2013, a retrospective analysis of a prospectively collected database was performed and supplemented with electronic medical charts review. Results Two hundred twenty extrapancreatic malignancies were found in 185 patients (22%) compared with expected 5% in the general population. Colorectal, lung, and renal cell carcinoma had significant observed/expected ratios (P

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalAmerican Journal of Surgery
Issue number3
StatePublished - Mar 1 2016



  • Autoimmune diseases
  • Extrapancreatic malignancies
  • Incidence
  • Intraductal papillary mucinous neoplasm

ASJC Scopus subject areas

  • Surgery

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