Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma

Safal Khanal, Pinakin Gunvant Davey, Lyne Racette, Madhu Thapa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluate the diagnostic capability of intraeye retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) asymmetry measurements for the discrimination of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT). Methods: A total of 90 subjects were enrolled including 30 consecutive healthy subjects, 30 consecutive subjects with POAG, and 30 consecutive subjects with NTG. RNFL thicknesses around the optic disc as well as MT measurements were taken with circular and radial SD-OCT scans. Intraeye retinal and MT asymmetry were calculated as the absolute difference between superior and inferior hemispheres of the eye using posterior pole asymmetry analysis protocol. Analysis of variance was used for comparison and areas under the receiver operating characteristic (AROC) were obtained for different parameters among the three diagnostic groups. Results: There was a significant difference in MT asymmetry for all comparison groups (normal-NTG, p

Original languageEnglish (US)
JournalJournal of Optometry
DOIs
StateAccepted/In press - Jul 26 2015

Fingerprint

Low Tension Glaucoma
Nerve Fibers
Optical Coherence Tomography
Optic Disk
ROC Curve
Analysis of Variance
Healthy Volunteers
Primary Open Angle Glaucoma

Keywords

  • Asymmetry
  • Glaucoma
  • Macular thickness
  • Retinal nerve fiber layer

ASJC Scopus subject areas

  • Optometry

Cite this

Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma. / Khanal, Safal; Davey, Pinakin Gunvant; Racette, Lyne; Thapa, Madhu.

In: Journal of Optometry, 26.07.2015.

Research output: Contribution to journalArticle

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