An ethanol-preferring line of rats, developed by selective breeding, consumed as much as 9.4±1.7 grams of ethanol per kilogram of body weight per day through intrasgastric self-infusions, yielding blood ethanol concentrations of 92 to 415 milligrams per 100 milliliters. By contrast, the ethanol-nonpreferring line self-administered only 0.7±0.2 gram per kilogram per day. These findings indicate that the reinforcing effect of ethanol is postabsorptive and is not mediated by the drug's smell or taste. Hence the ethanol-preferring line of rats may be a suitable animal model of alcoholism.
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