Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats

Marshall B. Waller, William J. McBride, Gregory J. Gatto, Lawrence Lumeng, Ting Kai Li

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Abstract

An ethanol-preferring line of rats, developed by selective breeding, consumed as much as 9.4±1.7 grams of ethanol per kilogram of body weight per day through intrasgastric self-infusions, yielding blood ethanol concentrations of 92 to 415 milligrams per 100 milliliters. By contrast, the ethanol-nonpreferring line self-administered only 0.7±0.2 gram per kilogram per day. These findings indicate that the reinforcing effect of ethanol is postabsorptive and is not mediated by the drug's smell or taste. Hence the ethanol-preferring line of rats may be a suitable animal model of alcoholism.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalScience
Volume225
Issue number4657
StatePublished - 1984

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Ethanol
Smell
Alcoholism
Animal Models
Body Weight
Pharmaceutical Preparations

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  • General

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Waller, M. B., McBride, W. J., Gatto, G. J., Lumeng, L., & Li, T. K. (1984). Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science, 225(4657), 78-80.

Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. / Waller, Marshall B.; McBride, William J.; Gatto, Gregory J.; Lumeng, Lawrence; Li, Ting Kai.

In: Science, Vol. 225, No. 4657, 1984, p. 78-80.

Research output: Contribution to journalArticle

Waller, MB, McBride, WJ, Gatto, GJ, Lumeng, L & Li, TK 1984, 'Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats', Science, vol. 225, no. 4657, pp. 78-80.
Waller MB, McBride WJ, Gatto GJ, Lumeng L, Li TK. Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science. 1984;225(4657):78-80.
Waller, Marshall B. ; McBride, William J. ; Gatto, Gregory J. ; Lumeng, Lawrence ; Li, Ting Kai. / Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. In: Science. 1984 ; Vol. 225, No. 4657. pp. 78-80.
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