Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and review of the literature

Doug Rex, Lawrence Lumeng, John Eble, Lois Rex

Research output: Contribution to journalReview article

23 Scopus citations


Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract. A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy. Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts. Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction. The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given. The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.

Original languageEnglish (US)
Pages (from-to)718-721
Number of pages4
Issue number3
StatePublished - Sep 1983


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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